分层蛋白（SFN）通过使Vps34-BECN1-TRAF6复合物成核以诱导自噬来调节肺癌进展。 - Suppr

Stratifin (SFN) regulates lung cancer progression via nucleating the Vps34-BECN1-TRAF6 complex for autophagy induction.

作者信息

Kim Ji Young, Kim Mi-Jeong, Lee Ji Su, Son Juhee, Kim Duk-Hwan, Lee Joo Sang, Jeong Soo-Kyung, Chun Eunyoung, Lee Ki-Young

机构信息

Department of Immunology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.

Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea.

出版信息

Clin Transl Med. 2022 Jun;12(6):e896. doi: 10.1002/ctm2.896.

DOI:10.1002/ctm2.896

PMID:35673887

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9174881/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0ddc/9174881/406a9edb6896/CTM2-12-e896-g004.jpg

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Pathol Int. 2021 Oct;71(10):655-665. doi: 10.1111/pin.13147. Epub 2021 Jul 29.

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Stratifin (SFN) regulates lung cancer progression via nucleating the Vps34-BECN1-TRAF6 complex for autophagy induction.

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