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设计——一种看待旧分子的新方法。

Design - a new way to look at old molecules.

机构信息

Laboratoire de Biochimie Théorique, CNRS, Université Paris Cité, UPR 9080, 13 rue Pierre et Marie Curie, F-75005, Paris, France.

Institut de Biologie Physico-Chimique - Fondation Edmond de Rothschild, Paris, France.

出版信息

J Integr Bioinform. 2022 Jul 1;19(2):20220020. doi: 10.1515/jib-2022-0020.

Abstract

We discuss how design enriches molecular science, particularly structural biology and bioinformatics. We present two use cases, one in academic practice and the other to design for outreach. The first case targets the representation of ion channels and their dynamic properties. In the second, we document a transition process from a research environment to general-purpose designs. Several testimonials from practitioners are given. By describing the design process of abstracted shapes, exploded views of molecular structures, motion-averaged slices, 360-degree panoramic projections, and experiments with lit sphere shading, we document how designers help make scientific data accessible without betraying its meaning, and how a creative mind adds value over purely data-driven visualizations. A similar conclusion was drawn for public outreach, as we found that comic-book-style drawings are better suited for communicating science to a broad audience.

摘要

我们讨论了设计如何丰富分子科学,特别是结构生物学和生物信息学。我们提出了两个用例,一个用于学术实践,另一个用于设计外展。第一个案例针对离子通道及其动态特性的表示。在第二个案例中,我们记录了从研究环境到通用设计的过渡过程。我们提供了几位从业者的证明。通过描述抽象形状的设计过程、分子结构的爆炸视图、运动平均切片、360 度全景投影以及带有点亮球体阴影的实验,我们记录了设计师如何在不改变其含义的情况下帮助使科学数据易于访问,以及创意思维如何在纯粹的数据驱动可视化之上增加价值。我们对外展也得出了类似的结论,因为我们发现漫画风格的绘画更适合向广大受众传播科学。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7f6c/9377703/fc00cdb83ed0/j_jib-2022-0020_fig_001.jpg

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