联合噬菌体-抗生素疗法控制耐药菌的益处：文献综述
Benefits of Combined Phage-Antibiotic Therapy for the Control of Antibiotic-Resistant Bacteria: A Literature Review.
作者信息
Diallo Kevin, Dublanchet Alain
机构信息
Department of Infective and Tropical Diseases and Internal Medicine, University Hospital of la Reunion, 97448 Saint-Pierre, France.
2465 Rue Céline Robert, 94300 Vincennes, France.
出版信息
Antibiotics (Basel). 2022 Jun 22;11(7):839. doi: 10.3390/antibiotics11070839.
Abstract
With the increase in bacterial resistance to antibiotics, more and more therapeutic failures are being reported worldwide. The market for antibiotics is now broken due to the high cost of developing new molecules. A promising solution to bacterial resistance is combined phage-antibiotic therapy, a century-old method that can potentiate existing antibiotics by prolonging or even restoring their activity against specific bacteria. The aim of this literature review was to provide an overview of different phage-antibiotic combinations and to describe the possible mechanisms of phage-antibiotic synergy.
摘要
随着细菌对抗生素耐药性的增加，全球范围内报告的治疗失败案例越来越多。由于开发新分子的成本高昂，抗生素市场目前已陷入困境。一种有前景的解决细菌耐药性的方法是噬菌体 - 抗生素联合疗法，这是一种有着百年历史的方法，它可以通过延长甚至恢复现有抗生素对特定细菌的活性来增强其效果。这篇文献综述的目的是概述不同的噬菌体 - 抗生素组合，并描述噬菌体 - 抗生素协同作用的可能机制。
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