低血糖指数地中海饮食与联合运动计划对代谢相关脂肪性肝病的影响：一种联合建模方法。

The Effect of Low Glycemic Index Mediterranean Diet and Combined Exercise Program on Metabolic-Associated Fatty Liver Disease: A Joint Modeling Approach.

作者信息

Curci Ritanna, Bianco Antonella, Franco Isabella, Campanella Angelo, Mirizzi Antonella, Bonfiglio Caterina, Sorino Paolo, Fucilli Fabio, Di Giovanni Giuseppe, Giampaolo Nicola, Pesole Pasqua Letizia, Osella Alberto Ruben

机构信息

Laboratory of Epidemiology and Statistics, National Institute of Gastroenterology, IRCCS, "S. de Bellis" Research Hospital, 70013 Castellana Grotte, BA, Italy.

Department of Electrical and Information Engineering, Polytechnic of Bari, 70126 Bari, BA, Italy.

出版信息

J Clin Med. 2022 Jul 26;11(15):4339. doi: 10.3390/jcm11154339.

DOI:10.3390/jcm11154339

PMID:35893431

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9330790/

Abstract

BACKGROUND

Excessive caloric intake and reduced energy expenditure are associated with the onset of metabolic-associated fatty liver disease (MAFLD). The aim of this study was to probe the benefits of a low glycemic index Mediterranean diet (LGIMD) and a combined exercise program (CEP) on MAFLD by monitoring the clinical process through anthropometric measurement, body mass index (BMI), and specific biomarkers, such as the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR).

METHODS

The study was conducted at the National Institute of Gastroenterology, 'S. de Bellis', Italy. Subjects were invited to join the study for 12 months.

RESULTS

54 participants were enrolled. Joint modeling of longitudinal and time-to-event data was applied. Overall, a statistically significant direct effect of LGIMD/CEP adherence on ln (BMI), a statistically significant direct effect of LGIMD/CEP adherence on time-to-event and a strong statistically significant direct effect of log (BMI) on time-to-event were observed. In addition, a statistically significant direct effect of LGIMD/CEP adherence on ln(HOMA-IR), a statistically significant direct effect of LGIMD/CEP adherence on time-to-event and a statistically significant direct effect of ln(HOMA-IR) on time-to-event were observed.

CONCLUSIONS

LGIMD/CEP significantly improved MAFLD status; in addition, longitudinal BMI and HOMA-IR were good predictors of the disappearance of diagnostic criteria for MAFLD.

摘要

背景

热量摄入过多和能量消耗减少与代谢相关脂肪性肝病（MAFLD）的发病有关。本研究的目的是通过人体测量、体重指数（BMI）和特定生物标志物（如胰岛素抵抗稳态模型评估（HOMA-IR））监测临床过程，探讨低血糖指数地中海饮食（LGIMD）和联合运动计划（CEP）对MAFLD的益处。

方法

该研究在意大利国家胃肠病学研究所“S. de Bellis”进行。邀请受试者参加为期12个月的研究。

结果

招募了54名参与者。应用纵向数据和事件发生时间数据的联合建模。总体而言，观察到LGIMD/CEP依从性对ln（BMI）有统计学显著的直接影响，对事件发生时间有统计学显著的直接影响，以及log（BMI）对事件发生时间有很强的统计学显著直接影响。此外，观察到LGIMD/CEP依从性对ln（HOMA-IR）有统计学显著的直接影响，对事件发生时间有统计学显著的直接影响，以及ln（HOMA-IR）对事件发生时间有统计学显著的直接影响。