用于治疗糖尿病的基于天然多糖的纳米药物递送系统
Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes.
作者信息
Qiu Aijun, Wang Yunyun, Zhang Genlin, Wang Hebin
机构信息
College of Chemical Engineering and Technology, Tianshui Normal University, Tianshui 741000, China.
Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi 832003, China.
出版信息
Polymers (Basel). 2022 Aug 8;14(15):3217. doi: 10.3390/polym14153217.
In recent years, natural polysaccharides have been considered as the ideal candidates for novel drug delivery systems because of their good biocompatibility, biodegradation, low immunogenicity, renewable source and easy modification. These natural polymers are widely used in the designing of nanocarriers, which possess wide applications in therapeutics, diagnostics, delivery and protection of bioactive compounds or drugs. A great deal of studies could be focused on developing polysaccharide nanoparticles and promoting their application in various fields, especially in biomedicine. In this review, a variety of polysaccharide-based nanocarriers were introduced, including nanoliposomes, nanoparticles, nanomicelles, nanoemulsions and nanohydrogels, focusing on the latest research progress of these nanocarriers in the treatment of diabetes and the possible strategies for further study of polysaccharide nanocarriers.
近年来，天然多糖因其良好的生物相容性、生物降解性、低免疫原性、可再生资源以及易于修饰等特性，被视为新型药物递送系统的理想候选物。这些天然聚合物广泛应用于纳米载体的设计中，纳米载体在生物活性化合物或药物的治疗、诊断、递送及保护方面具有广泛应用。大量研究聚焦于开发多糖纳米颗粒并促进其在各个领域的应用，尤其是在生物医学领域。在这篇综述中，介绍了多种基于多糖的纳米载体，包括纳米脂质体、纳米颗粒、纳米胶束、纳米乳液和纳米水凝胶，重点阐述了这些纳米载体在糖尿病治疗方面的最新研究进展以及多糖纳米载体进一步研究的可能策略。
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