头颈部鳞状细胞癌中脂质代谢重编程的研究进展：综述
Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview.
作者信息
Miao Xiangwan, Wang Beilei, Chen Kaili, Ding Rui, Wu Jichang, Pan Yi, Ji Peilin, Ye Bin, Xiang Mingliang
机构信息
Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.
出版信息
Front Oncol. 2022 Sep 16;12:1008361. doi: 10.3389/fonc.2022.1008361. eCollection 2022.
Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine metabolism. However, the mechanisms underlying lipid metabolism reprogramming in HNSCCs remains obscure. The present review summarizes and discusses the "vital" cellular signaling roles of the lipid metabolism reprogramming in HNSCCs. We also address the differences between HNSCCs regions caused by anatomical heterogeneity. We enumerate these recent findings into our current understanding of lipid metabolism reprogramming in HNSCCs and introduce the new and exciting therapeutic implications of targeting the lipid metabolism.
最近的研究表明，脂质代谢重编程通过干扰癌症中的能量产生、膜形成和信号转导，促进肿瘤发生和恶性发展。头颈部鳞状细胞癌高度依赖有氧糖酵解和谷氨酰胺代谢。然而，头颈部鳞状细胞癌中脂质代谢重编程的潜在机制仍不清楚。本综述总结并讨论了脂质代谢重编程在头颈部鳞状细胞癌中的“重要”细胞信号传导作用。我们还阐述了解剖学异质性导致的头颈部鳞状细胞癌不同区域之间的差异。我们将这些最新发现纳入对头颈部鳞状细胞癌脂质代谢重编程的当前理解中，并介绍靶向脂质代谢的新的、令人兴奋的治疗意义。
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