皮肤微生物群在特应性皮炎中的作用
The Role of the Cutaneous Mycobiome in Atopic Dermatitis.
作者信息
Szczepańska Milena, Blicharz Leszek, Nowaczyk Joanna, Makowska Karolina, Goldust Mohamad, Waśkiel-Burnat Anna, Czuwara Joanna, Samochocki Zbigniew, Rudnicka Lidia
机构信息
Department of Dermatology, Medial University of Warsaw, 02-008 Warsaw, Poland.
Department of Dermatology, University Medical Center, 55131 Mainz, Germany.
出版信息
J Fungi (Basel). 2022 Oct 31;8(11):1153. doi: 10.3390/jof8111153.
Atopic dermatitis is a chronic inflammatory skin disorder characterized by eczematous lesions, itch, and a significant deterioration in the quality of life. Recently, microbiome dysbiosis has been implicated in the pathogenesis of atopic dermatitis. Changes in the fungal microbiome (also termed mycobiome) appear to be an important factor influencing the clinical picture of this entity. This review summarizes the available insights into the role of the cutaneous mycobiome in atopic dermatitis and the new research possibilities in this field. The prevalence and characteristics of key fungal species, the most important pathogenesis pathways, as well as classic and emerging therapies of fungal dysbiosis and infections complicating atopic dermatitis, are presented.
特应性皮炎是一种慢性炎症性皮肤病，其特征为湿疹样皮损、瘙痒以及生活质量显著下降。最近，微生物群失调被认为与特应性皮炎的发病机制有关。真菌微生物群（也称为真菌组）的变化似乎是影响该疾病临床表现的一个重要因素。本综述总结了关于皮肤真菌组在特应性皮炎中的作用的现有见解以及该领域的新研究可能性。介绍了关键真菌物种的患病率和特征、最重要的发病机制途径，以及真菌失调和特应性皮炎并发感染的经典和新兴治疗方法。
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