比较行胚胎植入前遗传学检测的冻融 D5 期和 D6 期囊胚的临床结局。
Comparison of clinical outcomes of frozen-thawed D5 and D6 blastocysts undergoing preimplantation genetic testing.
机构信息
Center for Reproductive Medicine, Shandong University, Jinan, 250012, Shandong, China.
Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, 250021, Shandong, China.
出版信息
J Transl Med. 2022 Nov 26;20(1):545. doi: 10.1186/s12967-022-03762-4.
BACKGROUND
This study aimed to analyze the clinical outcomes of blastocyst which undergo the preimplantation genetic testing (PGT) transplantation from frozen-thawed D5 and D6. In addition, the effect of blastocyst grade on clinical and neonatal outcomes was also investigated in this study.
METHODS
The pregnancy and miscarriage rates of 1130 cycles of frozen embryo transfer, including 784 D5 frozen embryos and 346 D6 frozen embryos in the Reproductive Hospital of Shandong University from January to December 2020 were analyzed. Gardner blastocyst scoring was used for blastocyst evaluation.
RESULTS
The pregnancy rate of D5 blastocyst was significantly higher, whereas the miscarriage rate of D5 blastocyst was lower, than that of D6 blastocyst tissue biopsy. No significant difference was observed in birth weight and low birth weight of D5 blastocyst and D6 blastocyst, preterm birth, gestational age, and neonatal sex. Frozen-thawed D5 blastocysts have higher pregnancy success rates and lower miscarriage rates compared to D6 blastocysts.
CONCLUSION
Therefore, both blastocyst grade and embryo biopsy date must be considered when transferring frozen embryos.
背景
本研究旨在分析冷冻解冻 D5 和 D6 期胚胎进行种植前遗传学检测（PGT）移植的临床结局。此外，本研究还探讨了囊胚等级对临床和新生儿结局的影响。
方法
分析 2020 年 1 月至 12 月在山东大学生殖医院进行的 1130 个冷冻胚胎移植周期的妊娠和流产率，其中包括 784 个 D5 冷冻胚胎和 346 个 D6 冷冻胚胎。采用 Gardner 囊胚评分法对囊胚进行评估。
结果
D5 囊胚的妊娠率显著高于 D6 囊胚，而 D5 囊胚的流产率则低于 D6 囊胚。D5 囊胚和 D6 囊胚的出生体重和低出生体重、早产、胎龄和新生儿性别无显著差异。与 D6 囊胚相比，冷冻解冻 D5 囊胚具有更高的妊娠成功率和更低的流产率。
结论
因此，在移植冷冻胚胎时，必须考虑囊胚等级和胚胎活检日期。
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