特应性皮炎患者白细胞介素-33基因的血清水平及单核苷酸多态性
Serum levels and single nucleotide polymorphisms of the interleukin-33 gene in atopic dermatitis.
作者信息
Zaryczañska Anna, Gleñ Jolanta, Zabłotna Monika, Nowicki Roman J, Trzeciak Magdalena
机构信息
Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.
出版信息
Postepy Dermatol Alergol. 2022 Oct;39(5):959-964. doi: 10.5114/ada.2022.113130. Epub 2022 Mar 3.
INTRODUCTION
Interleukin 33 (IL-33) is considered significant in the pathogenesis of atopic dermatitis (AD).
AIM
To determine the correlation between the serum levels of IL-33 and single nucleotide polymorphisms of its gene in the -9894 T/C (rs1929992) and -11877 C/T (rs10975519) loci and the course of AD.
MATERIAL AND METHODS
The study group consisted of 191 patients with AD and 168 controls.
RESULTS
The TT genotype appeared to be most frequent in patients with severe pruritus (OR = 6.69, 95% CI: 1.24-35.99, = 0.01).
CONCLUSIONS
The results of our study are particularly important in the light of personalized medicine and might significantly contribute to further studies in this field.
引言
白细胞介素33（IL-33）被认为在特应性皮炎（AD）的发病机制中具有重要意义。
目的
确定血清IL-33水平与其基因在-9894 T/C（rs1929992）和-11877 C/T（rs10975519）位点的单核苷酸多态性之间的相关性以及AD的病程。
材料与方法
研究组由191例AD患者和168例对照组成。
结果
TT基因型在严重瘙痒患者中似乎最为常见（OR = 6.69，95% CI：1.24 - 35.99，P = 0.01）。
结论
鉴于个性化医疗，我们的研究结果尤为重要，可能会对该领域的进一步研究做出重大贡献。
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