NSP7 肽能够形成类淀粉样纤维：是人为假象还是药物设计的挑战？
Peptide from NSP7 is able to form amyloid-like fibrils: Artifact or challenge to drug design?
机构信息
Petersburg Nuclear Physics Institute named by B. P. Konstantinov of National Research Center, Kurchatov Institute, 1 mkr. Orlova roshcha, Gatchina 188300, Russia.
Saint Petersburg State University, 7/9 Universitetskaya Emb., St Petersburg 199034, Russia.
出版信息
Biochim Biophys Acta Proteins Proteom. 2023 Feb 1;1871(2):140884. doi: 10.1016/j.bbapap.2022.140884. Epub 2022 Dec 1.
Abstract
• We found potential amyloidogenic fragment in NSP7 SARS-CoV2 protein • NSP7 (52–62) fragment is able to form amyloid-like fibrils. • The possibility of using such a peptide as the basis for an antiviral drug is discussed.
摘要
• 我们在 SARS-CoV2 蛋白 NSP7 中发现了潜在的淀粉样蛋白片段。
• NSP7（52–62）片段能够形成类似淀粉样的纤维。
• 讨论了使用这种肽作为抗病毒药物基础的可能性。
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