饮食因素与表皮生长因子受体突变状态和组织学亚型的肺癌风险。

Dietary factors and the risk of lung cancer by epidermal growth factor receptor mutation status and histological subtypes.

机构信息

Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.

Division of Medical Oncology, National Cancer Centre Singapore, Singapore, Singapore.

出版信息

Front Public Health. 2022 Dec 2;10:1079543. doi: 10.3389/fpubh.2022.1079543. eCollection 2022.

DOI:10.3389/fpubh.2022.1079543

PMID:36530673

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9755194/

Abstract

BACKGROUND

Previous studies have reported differential associations of certain dietary factors such as soy consumption by epidermal growth factor receptor mutant ( +) subtype of non-small cell lung cancer (NSCLC). However, whether the other dietary factors including meat, fruits, and vegetables have differential risks on different histological and molecular subtypes of lung cancer remains unclear. Therefore, we conducted a case-control study to evaluate these associations.

METHODS

A total of 3,170 cases and 4,238 controls from three different studies (Genes and Environment in Lung Cancer Study, Lung Cancer Consortium Singapore Study, and Multi-ethnic Cohort Study) were included. Information on demographics, lifestyle, and dietary consumption was obtained using questionnaires. Diet was assessed by using the number of standard servings of each item consumed per week. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between meat, vegetables, and fruits consumption with lung cancer risk after adjusting for potential confounders.

RESULTS

We identified a significant inverse association between higher consumption of fruits and the risk of lung cancer (2nd tertile: OR = 0.54, 95%CI = 0.46-0.65; 3rd tertile: OR = 0.77, 95%CI = 0.65-0.91), compared with the lower (1st tertile) consumption of fruits. Higher vegetable consumption was significantly associated with a lower risk of + lung cancer (OR = 0.69, 95% CI = 0.54-0.88), however, this association was not significant among wild-type (-) lung cancer. Conversely, higher consumption of total meat (OR = 2.10, 95%CI = 1.58-2.79) was significantly associated with higher lung cancer risk, as compared with the lower consumption group.

CONCLUSIONS

Differential associations between vegetable consumption with mutation status in NSCLC were found. Further prospective studies are warranted to assess this association and elucidate the biological mechanisms.

摘要

背景

先前的研究报告称，表皮生长因子受体突变（+）亚型非小细胞肺癌（NSCLC）患者的某些饮食因素（如大豆摄入）存在差异关联。然而，其他饮食因素（包括肉类、水果和蔬菜）对不同组织学和分子亚型肺癌的风险是否存在差异尚不清楚。因此，我们进行了一项病例对照研究来评估这些关联。

方法

共有来自三项不同研究（肺癌基因与环境研究、新加坡肺癌联盟研究和多民族队列研究）的 3170 例病例和 4238 例对照纳入本研究。使用问卷获取人口统计学、生活方式和饮食摄入信息。通过每周摄入每种食物的标准份数来评估饮食。多变量逻辑回归用于估计肉类、蔬菜和水果摄入量与肺癌风险之间的关联，调整潜在混杂因素后，使用比值比（OR）和 95%置信区间（CI）进行评估。

结果

我们发现，与低水果摄入量（1 分位）相比，较高的水果摄入量与肺癌风险呈显著负相关（2 分位：OR = 0.54，95%CI = 0.46-0.65；3 分位：OR = 0.77，95%CI = 0.65-0.91）。较高的蔬菜摄入量与肺癌（+）显著相关（OR = 0.69，95%CI = 0.54-0.88），但在野生型（-）肺癌中无显著相关性。相反，与低肉类摄入量组相比，总肉类（OR = 2.10，95%CI = 1.58-2.79）摄入量较高与肺癌风险增加显著相关。