单细胞分析和深度免疫表型分析在理解免疫治疗心脏毒性中的作用
The Role of Single-Cell Profiling and Deep Immunophenotyping in Understanding Immune Therapy Cardiotoxicity.
作者信息
Huang Yuhsin Vivian, Waliany Sarah, Lee Daniel, Galdos Francisco X, Witteles Ronald M, Neal Joel W, Fan Alice C, Maecker Holden T, Nguyen Patricia K, Wu Sean M, Zhu Han
机构信息
Stanford Cardiovascular Institute, Stanford University, Stanford, California, USA.
Cornell University, Ithaca, New York, USA.
出版信息
JACC CardioOncol. 2022 Dec 20;4(5):629-634. doi: 10.1016/j.jaccao.2022.08.012. eCollection 2022 Dec.
Abstract
• ICIs used in cancer therapy can cause serious cardiac immune-related side effects. • Single-cell multi-omics are powerful tools in understanding cell subsets/phenotypes. • Multi-omics technology can elucidate disease mechanisms in ICI-induced myocarditis.
摘要
• 用于癌症治疗的免疫检查点抑制剂（ICIs）可引起严重的心脏免疫相关副作用。
• 单细胞多组学是理解细胞亚群/表型的强大工具。
• 多组学技术可以阐明免疫检查点抑制剂诱导的心肌炎的疾病机制。
Zotero 插件