PI3K-AKT 靶向乳腺癌治疗药物：天然产物和合成化合物。
PI3K-AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds.
机构信息
Medical Research Center, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha 410004, China.
School of Pharmacy, Hengyang Medical School, University of South China, Hengyang 421001, China.
出版信息
Biomolecules. 2023 Jan 2;13(1):93. doi: 10.3390/biom13010093.
Breast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K-AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown that natural products and synthetic drugs targeting PI3K-AKT signaling have the potential to treat breast cancer. In this review, we discuss the role of the PI3K-AKT signaling pathway in the occurrence and development of breast cancer and highlight PI3K-AKT-targeting natural products and drugs in clinical trials for the treatment of breast cancer.
乳腺癌是女性最常见的癌症。乳腺癌的发病率很高，且仍在不断上升，这使得治疗成为一个重大挑战。PI3K-AKT 通路及其下游靶标影响着各种细胞过程。近年来，越来越多的证据表明，针对 PI3K-AKT 信号的天然产物和合成药物具有治疗乳腺癌的潜力。在这篇综述中，我们讨论了 PI3K-AKT 信号通路在乳腺癌发生和发展中的作用，并强调了 PI3K-AKT 靶向天然产物和药物在治疗乳腺癌的临床试验中的应用。
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