随着年龄增长，血清中二氢睾酮浓度降低伴随着血管状态受损。

Age-related decrease in serum dihydrotestosterone concentration is accompanied by impaired vascular status.

机构信息

Chair of Exercise Physiology and Muscle Bioenergetics, Faculty of Health Sciences, Jagiellonian University Medical College, Ul. Skawinska 8, 31-066 Krakow, Poland.

出版信息

Exp Gerontol. 2023 Mar;173:112104. doi: 10.1016/j.exger.2023.112104. Epub 2023 Jan 21.

DOI:10.1016/j.exger.2023.112104

PMID:36693531

Abstract

INTRODUCTION

The effect of androgens on the cardiovascular system in humans is ambiguous. Moreover, still little is known about the effects of the most potent androgen, dihydrotestosterone, on arterial stiffness and endothelial function. The aim of this study was to evaluate whether age-dependent alterations in serum concentration of dihydrotestosterone and its circulating metabolite are accompanied by changes in endothelial function and arterial stiffness.

METHODS

In 12 young and 11 older men, basal serum concentrations of testosterone, dehydroepiandrosterone sulfate (DHAE-S), androstenedione (AE), dihydrotestosterone (DHT) and androstanediol glucuronide (ADG) were analyzed in relation to vascular status including cIMT - carotid intima media thickness, cAI - central augmentation index, crPWV - carotid radial pulse wave velocity, SI - stiffness index, endothelial and inflammatory markers.

RESULTS

Although concentration of testosterone was not different between young and older group, it was demonstrated that DHT, DHEA-S, AE and ADG were significantly lower in older men in comparison to young men (p < 0.01). Interestingly the most surprising difference was found for DHT concentration, that was as much as 61 % lower in aged men that displayed significantly higher values of cIMT, AI, crPWV and SI (p < 10), suggestive of arterial stiffness. Furthermore, DHT was negatively correlated to all arterial wall parameters (cAI, crPWV, SI and cIMT), c-reactive protein (CRP) and hyaluronic acid (HA) concentration, as well as positively correlated to markers of endothelial function (MNA and 6-keto-PGF) in all studied individuals (n = 23).

CONCLUSIONS

We have shown that ageing leads to a significant decrease in DHT concentration that is accompanied by impaired arterial wall characteristics and worsened endothelial function. Therefore more attention should be paid to the DHT, DHEA-S and ADG concentrations as a biomarkers for vascular dysfunction in ageing men.

摘要

简介

雄激素对人体心血管系统的影响尚不清楚。此外，关于最强效的雄激素二氢睾酮对动脉僵硬和内皮功能的影响，人们知之甚少。本研究旨在评估年龄相关的二氢睾酮及其循环代谢物血清浓度的变化是否伴有内皮功能和动脉僵硬的变化。

方法

在 12 名年轻男性和 11 名老年男性中，分析了基础血清睾酮、硫酸脱氢表雄酮 (DHEA-S)、雄烯二酮 (AE)、二氢睾酮 (DHT) 和雄烷二醇葡萄糖醛酸 (ADG)浓度与血管状况的关系，包括颈动脉内膜中层厚度 (cIMT)、中心增强指数 (cAI)、颈动脉径向脉搏波速度 (crPWV)、僵硬度指数 (SI)、内皮和炎症标志物。

结果

尽管年轻组和老年组之间的睾酮浓度没有差异，但研究表明，与年轻男性相比，老年男性的 DHT、DHEA-S、AE 和 ADG 浓度明显较低（p<0.01）。有趣的是，最令人惊讶的差异是 DHT 浓度，老年男性的 DHT 浓度低了 61%，而这些男性的 cIMT、AI、crPWV 和 SI 值较高（p<0.01），提示动脉僵硬。此外，在所有研究对象（n=23）中，DHT 与所有动脉壁参数（cAI、crPWV、SI 和 cIMT）、C 反应蛋白 (CRP) 和透明质酸 (HA)浓度呈负相关，与内皮功能标志物（MNA 和 6-酮-PGF）呈正相关。