精神分裂症认知表现的个体内变异性：关键文献综述及拟议研究议程
Within-individual variability in cognitive performance in schizophrenia: A narrative review of the key literature and proposed research agenda.
机构信息
Department of Psychiatry and Mental Health, University of Cape Town, South Africa.
Department of Psychiatry and Mental Health, University of Cape Town, South Africa; Biomedical Research and Innovation Platform, South African Medical Research Council, South Africa.
出版信息
Schizophr Res. 2023 Feb;252:329-334. doi: 10.1016/j.schres.2023.01.028. Epub 2023 Jan 26.
Schizophrenia is a neurodevelopmental disorder and a leading cause of disability worldwide. Deficits in cognitive function are characteristic of schizophrenia and are predictors of functional outcomes in the disorder. Within-individual variability (WIV) in cognitive performance is elevated in schizophrenia and has been suggested to provide additional insight into cognitive function over and above mean performance measures. Despite growing interest in WIV in schizophrenia, research on the clinical significance and neural correlates of WIV in the disorder remains sparse. The present narrative review summarizes the key literature linking WIV in schizophrenia to clinical, neural, and genetic correlates. Here, we aim to highlight key knowledge gaps and provide directions for future research into WIV in schizophrenia.
精神分裂症是一种神经发育障碍，也是全球范围内导致残疾的主要原因。认知功能缺陷是精神分裂症的特征，也是该疾病功能结果的预测因素。精神分裂症患者的认知表现个体内变异性（WIV）升高，并且有人认为，与平均表现测量相比，它可以提供对认知功能的额外深入了解。尽管人们对精神分裂症中的 WIV 越来越感兴趣，但关于该疾病中 WIV 的临床意义和神经相关性的研究仍然很少。本综述总结了将精神分裂症中的 WIV 与临床、神经和遗传相关性联系起来的关键文献。在这里，我们旨在强调关键的知识差距，并为未来精神分裂症中的 WIV 研究提供方向。
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