评估慢性阻塞性肺疾病患者的甲状腺功能试验。
Assessment of thyroid function tests in patients with chronic obstructive pulmonary disease.
机构信息
Department of Medicine, College of Medicine, University of Kufa, Najaf, Iraq.
Babylon Health Directorate, Alsadiq Teaching Hospital, Babylon, Iraq.
出版信息
J Med Life. 2022 Dec;15(12):1532-1535. doi: 10.25122/jml-2022-0069.
Chronic obstructive pulmonary disease (COPD), a group of diseases of distinct aetio-pathological consideration with different phenotypic presentations where smoking is the leading cause, all share the ultimate result of airflow limitation. This study aimed to evaluate thyroid function tests (TFT) in patients with COPD. Pulmonary function tests (PFT) were performed for 30 patients with obstructive lung disease and fifteen healthy control individuals. We measured SPO to confirm COPD and assess the severity of the disease and assessed TT3, TT4, and TSH using the ELISA test. The values of VC, FVC, and FEV in the first second and PEF, TSH, and SPO were lower in the COPD group than in the control group (P-value=0.001). In severe COPD (FEV<50%), there was a significant reduction in T3 but not T4 or TSH compared to mild-moderate COPD patients. Thyroid dysfunction was observed in patients with COPD pointing to a metabolic response; patients with lower weight indices had a lower TSH and, consequently, T3.
慢性阻塞性肺疾病（COPD），一组具有不同表型表现和特定病因病理考虑的疾病，其中吸烟是主要原因，都共享气流受限的最终结果。本研究旨在评估 COPD 患者的甲状腺功能测试（TFT）。对 30 名阻塞性肺病患者和 15 名健康对照组进行了肺功能测试（PFT）。我们测量了 SPO 以确认 COPD，并评估疾病的严重程度，并使用 ELISA 测试测量 TT3、TT4 和 TSH。COPD 组的 VC、FVC、FEV 在第一秒和 PEF、TSH 和 SPO 的值低于对照组（P 值=0.001）。在严重 COPD（FEV<50%）中，与轻度至中度 COPD 患者相比，T3 显著降低，但 T4 或 TSH 没有降低。在 COPD 患者中观察到甲状腺功能障碍，表明存在代谢反应；体重指数较低的患者 TSH 较低，因此 T3 也较低。
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