探索天然化合物与化疗药物联合用于肿瘤治疗的应用。
Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment.
机构信息
Center for Drug Safety Evaluation and Research, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
出版信息
Molecules. 2023 Jan 19;28(3):1022. doi: 10.3390/molecules28031022.
Currently, chemotherapy is the main treatment for tumors, but there are still problems such as unsatisfactory chemotherapy results, susceptibility to drug resistance, and serious adverse effects. Natural compounds have numerous pharmacological activities which are important sources of drug discovery for tumor treatment. The combination of chemotherapeutic drugs and natural compounds is gradually becoming an important strategy and development direction for tumor treatment. In this paper, we described the role of natural compounds in combination with chemotherapeutic drugs in synergizing, reducing drug resistance, mitigating adverse effects and related mechanisms, and providing new insights for future oncology research.
目前，化疗是肿瘤的主要治疗方法，但仍存在化疗效果不理想、易产生耐药性、不良反应严重等问题。天然化合物具有多种药理活性，是肿瘤治疗药物发现的重要来源。化疗药物与天然化合物联合逐渐成为肿瘤治疗的重要策略和发展方向。本文阐述了天然化合物与化疗药物联合在协同作用、降低耐药性、减轻不良反应及相关机制中的作用，为肿瘤的未来研究提供了新的思路。
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