检测精液中 SARS-CoV-2 抗体的变化及其与精子参数的关系。
Detection of antibodies to SARS-CoV-2 after vaccination in seminal plasma and their association to sperm parameters.
机构信息
Institute for Experimental Endocrinology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Max Rubner Center for Cardiovascular Metabolic Renal Research, Berlin, Germany.
Das Kinderwunsch Institut Schenk GmbH, Am Sendergrund 11, Dobl, Austria.
出版信息
Int J Infect Dis. 2023 May;130:161-165. doi: 10.1016/j.ijid.2023.03.018. Epub 2023 Mar 16.
There is a public concern that COVID-19 vaccination and SARS-CoV-2 antibodies (Abs) negatively affect male fertility. However, the evidence for the presence of SARS-CoV-2 Abs in seminal plasma (SP) is lacking. We examined whether Abs were detectable in SP after COVID-19 vaccination in 86 men using a direct Ab measurement and by quantification of their neutralizing activity. The results show the presence of SARS-CoV-2 Abs in SP, with a strong correlation to the serum Abs, increasing with the number of vaccinations. Furthermore, the Ab titers are correlating with the neutralization activity. The SARS-CoV-2 vaccination parameters showed no association with the markers of sperm quality. In conclusion, this study indicates substantial levels of Abs in SP after COVID-19 vaccination that correlate with serum Ab titers but do not associate with sperm quality.
人们普遍担心 COVID-19 疫苗接种和 SARS-CoV-2 抗体 (Abs) 会对男性生育力产生负面影响。然而，关于 SARS-CoV-2 Abs 在精液中的存在尚无证据。我们使用直接 Ab 测量法和中和活性定量法，检查了 86 名男性在 COVID-19 接种疫苗后 SP 中是否可检测到 Abs。结果表明 SP 中存在 SARS-CoV-2 Abs，与血清 Abs 具有很强的相关性，随着接种次数的增加而增加。此外，Ab 滴度与中和活性相关。SARS-CoV-2 疫苗接种参数与精子质量标志物无关。总之，本研究表明 COVID-19 接种疫苗后 SP 中存在大量 Abs，与血清 Ab 滴度相关，但与精子质量无关。
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