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环境内分泌干扰物:关注女性生殖健康与子宫内膜异位症。

Endocrine Disruptor Compounds in Environment: Focus on Women's Reproductive Health and Endometriosis.

机构信息

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98166 Messina, Italy.

Department of Veterinary Science, University of Messina, 98168 Messina, Italy.

出版信息

Int J Mol Sci. 2023 Mar 16;24(6):5682. doi: 10.3390/ijms24065682.

Abstract

Endometriosis is an estrogen-dependent gynecologic illness that has long-term effects on a woman's fertility, physical health, and overall quality of life. Growing evidence suggests that endocrine-disrupting chemicals (EDCs) may be etiologically involved in the development and severity of the disease. We consider the available human evidence on EDCs and endometriosis, limiting ourselves to studies that have individually assessed chemical amounts in women. Dioxins, BPA, Phthalates, and other endocrine disruptors, like DDT, are among the evidence indicating an environmental etiology for endometriosis. Collectively, this review describes how environmental toxins are linked to lower fertility in women, as well as a number of reproductive diseases, focusing on the pathology of endometriosis and its treatments. Importantly, this review can be used to investigate techniques for preventing the negative effects of EDC exposure.

摘要

子宫内膜异位症是一种雌激素依赖性妇科疾病,会对女性的生育能力、身体健康和整体生活质量产生长期影响。越来越多的证据表明,内分泌干扰化学物质(EDCs)可能与疾病的发展和严重程度有关。我们考虑了 EDCs 和子宫内膜异位症的现有人类证据,仅限于单独评估女性体内化学物质含量的研究。二恶英、双酚 A、邻苯二甲酸盐和其他内分泌干扰物,如滴滴涕,都表明环境病因与子宫内膜异位症有关。总的来说,这篇综述描述了环境毒素如何与女性生育能力下降以及许多生殖疾病有关,重点关注子宫内膜异位症的病理学及其治疗方法。重要的是,这篇综述可用于研究预防 EDC 暴露负面影响的技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1ba/10058284/73034ab129bf/ijms-24-05682-g001.jpg

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