Zhang Niu, Lei Tianyao, Xu Tianwei, Zou Xiaoteng, Wang Zhaoxia
Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Respiratory Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Front Oncol. 2023 Mar 28;13:1108564. doi: 10.3389/fonc.2023.1108564. eCollection 2023.
As oncogenes or tumor suppressor genes, lncRNAs played an important role in tumorigenesis and the progression of human cancers. The lncRNA SNHG15 has recently been revealed to be dysregulated in malignant tumors, suggesting the aberrant expression of which contributes to clinical features and regulates various oncogenic processes. We have selected extensive literature focused on SNHG15 from electronic databases, including studies relevant to its clinical significance and the critical events in cancer-related processes such as cell proliferation, apoptosis, autophagy, metastasis, and drug resistance. This review summarized the current understanding of SNHG15 in cancer, mainly focusing on the pathological features, known biological functions, and underlying molecular mechanisms. Furthermore, SNHG15 has been well-documented to be an effective diagnostic and prognostic marker for tumors, offering novel therapeutic interventions in specific subsets of cancer cells.
作为癌基因或肿瘤抑制基因,长链非编码RNA(lncRNAs)在肿瘤发生及人类癌症进展中发挥着重要作用。最近有研究表明,lncRNA SNHG15在恶性肿瘤中表达失调,提示其异常表达与临床特征相关,并调控多种致癌过程。我们从电子数据库中筛选了大量聚焦于SNHG15的文献,包括与其临床意义以及癌症相关过程(如细胞增殖、凋亡、自噬、转移和耐药性)中的关键事件相关的研究。本综述总结了目前对SNHG15在癌症中的认识,主要聚焦于其病理特征、已知生物学功能及潜在分子机制。此外,已有充分证据表明SNHG15是一种有效的肿瘤诊断和预后标志物,为特定癌细胞亚群提供了新的治疗干预手段。