CD147 在肝细胞癌发生发展及诊断中的作用。
Role of CD147 in the development and diagnosis of hepatocellular carcinoma.
机构信息
Laboratory Medicine, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
Department of Cardiothoracic Surgery, First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
出版信息
Front Immunol. 2023 Apr 6;14:1149931. doi: 10.3389/fimmu.2023.1149931. eCollection 2023.
Hepatocellular carcinoma (HCC) is the most common primary liver cancer, and the third leading cause of cancer-related deaths worldwide. HCC is characterized by insidious onset, and most patients are diagnosed at an advanced stage with a poor prognosis. Identification of biomarkers for HCC onset and progression is imperative to development of effective diagnostic and therapeutic strategies. CD147 is a glycoprotein that is involved in tumor cell invasion, metastasis and angiogenesis through multiple mechanisms. In this review, we describe the molecular structure of CD147 and its role in regulating HCC invasion, metastasis and angiogenesis. We highlight its potential as a diagnostic and therapeutic target for HCC.
肝细胞癌（HCC）是最常见的原发性肝癌，也是全球癌症相关死亡的第三大主要原因。HCC 的特点是隐匿性发病，大多数患者在晚期被诊断，预后不良。确定 HCC 发病和进展的生物标志物对于开发有效的诊断和治疗策略至关重要。CD147 是一种糖蛋白，通过多种机制参与肿瘤细胞的侵袭、转移和血管生成。在这篇综述中，我们描述了 CD147 的分子结构及其在调节 HCC 侵袭、转移和血管生成中的作用。我们强调了它作为 HCC 诊断和治疗靶点的潜力。
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