热休克反应：疟原虫生存的全身性和本质性途径。
Heat-shock responses: systemic and essential ways of malaria parasite survival.
机构信息
Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, FL, United States.
Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, FL, United States; Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
出版信息
Curr Opin Microbiol. 2023 Jun;73:102322. doi: 10.1016/j.mib.2023.102322. Epub 2023 Apr 30.
Fever is a part of the human innate immune response that contributes to limiting microbial growth and development in many infectious diseases. For the parasite Plasmodium falciparum, survival of febrile temperatures is crucial for its successful propagation in human populations as well as a fundamental aspect of malaria pathogenesis. This review discusses recent insights into the biological complexity of the malaria parasite's heat-shock response, which involves many cellular compartments and essential metabolic processes to alleviate oxidative stress and accumulation of damaged and unfolded proteins. We highlight the overlap between heat-shock and artemisinin resistance responses, while also explaining how the malaria parasite adapts its fever response to fight artemisinin treatment. Additionally, we discuss how this systemic and essential fight for survival can also contribute to parasite transmission to mosquitoes.
发热是人体固有免疫反应的一部分，有助于在许多传染病中限制微生物的生长和繁殖。对于寄生虫疟原虫来说，在发热温度下的存活对于其在人群中的成功繁殖以及疟疾发病机制的一个基本方面至关重要。本综述讨论了最近对疟原虫热休克反应的生物学复杂性的深入了解，该反应涉及许多细胞区室和重要的代谢过程，以减轻氧化应激和受损及未折叠蛋白的积累。我们强调了热休克反应和青蒿素耐药反应之间的重叠，同时也解释了疟原虫如何适应发热反应来对抗青蒿素治疗。此外，我们还讨论了这种全身性和必不可少的生存斗争如何有助于寄生虫向蚊子传播。
Zotero 插件