低分子量巯基在宿主-微生物界面的新兴作用。
Emerging roles of low-molecular-weight thiols at the host-microbe interface.
机构信息
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 06520, USA; Department of Chemistry, Yale University, New Haven, CT, 06520, USA; Microbial Sciences Institute, Yale University, West Haven, CT, 06516, USA.
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, 06520, USA; Department of Chemistry, Yale University, New Haven, CT, 06520, USA; Microbial Sciences Institute, Yale University, West Haven, CT, 06516, USA.
出版信息
Curr Opin Chem Biol. 2023 Aug;75:102322. doi: 10.1016/j.cbpa.2023.102322. Epub 2023 May 16.
Low-molecular-weight (LMW) thiols are an abundant class of cysteine-derived small molecules found in all forms of life that maintain reducing conditions within cells. While their contributions to cellular redox homeostasis are well established, LMW thiols can also mediate other aspects of cellular physiology, including intercellular interactions between microbial and host cells. Here we discuss emerging roles for these redox-active metabolites at the host-microbe interface. We begin by providing an overview of chemical and computational approaches to LMW-thiol discovery. Next, we highlight mechanisms of virulence regulation by LMW thiols in infected cells. Finally, we describe how microbial metabolism of these compounds may influence host physiology.
低分子量（LMW）巯基是一类丰富的半胱氨酸衍生的小分子，存在于所有形式的生命中，可维持细胞内的还原条件。虽然它们对细胞氧化还原稳态的贡献已得到充分证实，但 LMW 巯基也可以介导细胞生理学的其他方面，包括微生物和宿主细胞之间的细胞间相互作用。在这里，我们讨论了这些氧化还原活性代谢物在宿主-微生物界面的新作用。我们首先提供了一种用于 LMW-硫醇发现的化学和计算方法概述。接下来，我们强调了 LMW 巯基在感染细胞中调节毒力的机制。最后，我们描述了微生物对这些化合物的代谢如何影响宿主生理学。
Zotero 插件