低骨密度——北非和中东地区被忽视的状况：来自1990 - 2019年全球疾病负担研究的估计数据
Low bone mineral density, a neglected condition in North Africa and Middle East: estimates from the Global Burden of Disease Study, 1990-2019.
作者信息
Rashidi Mohammad-Mahdi, Saeedi Moghaddam Sahar, Azadnajafabad Sina, Heidari-Foroozan Mahsa, Hashemi Seyedeh Melika, Mohammadi Esmaeil, Esfahani Zahra, Ebrahimi Narges, Shobeiri Parnian, Malekpour Mohammad-Reza, Abbasi-Kangevari Mohsen, Rashedi Sina, Mohammadi Fateh Sahar, Larijani Bagher, Farzadfar Farshad
机构信息
Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Kiel Institute for the World Economy, Kiel, Germany.
出版信息
Osteoporos Int. 2023 Sep;34(9):1577-1589. doi: 10.1007/s00198-023-06778-8. Epub 2023 May 23.
UNLABELLED
Due to the high prevalence of low bone mineral density in North Africa and Middle East region, estimating its attributable burden would help to a better understanding of this neglected condition for policymakers and health researchers. This study presented the number of attributable deaths has doubled from 1990 to 2019.
PURPOSE
This study provides the latest estimates of the burden of low bone mineral density (BMD) from 1990 to 2019 in North Africa and Middle East (NAME) region.
METHODS
The data were extracted from the global burden of disease (GBD) 2019 study to estimate epidemiological indices such as deaths, disability-adjusted life years (DALYs), and summary exposure value (SEV). SEV is a measure of the exposure of the population to a risk factor that considers the amount of exposure by the level of risk.
RESULTS
Our findings showed that in 1990-2019, the number of deaths and DALYs attributable to low BMD had almost doubled in the region and caused 20,371 (95% uncertainty intervals: 14,848-24,374) deaths and 805,959 (630,238-959,581) DALYs in 2019. However, DALYs and death rates showed a decreasing trend after age standardization. Saudi Arabia had the highest, and Lebanon had the lowest age-standardized DALYs rates in 2019, with rates of 434.2 (329.6-534.3) and 90.3 (70.6-112.1) per 100,000, respectively. The highest burden attributable to low BMD was in the 90-94 and over 95 age groups. Also, there was a decreasing trend in age-standardized SEV to low BMD for both sexes.
CONCLUSION
Despite the decreasing trend of age-standardized burden indices, considerable amounts of deaths and DALYs were attributable to low BMD, especially in the elderly population, in the region in 2019. As the positive effects of proper interventions will be detectable in the long term, robust strategies and comprehensive stable policies are the ultimate solutions to achieving desired goals.
未标注
由于北非和中东地区低骨矿物质密度的高患病率，估计其可归因负担将有助于政策制定者和健康研究人员更好地了解这一被忽视的状况。本研究表明，1990年至2019年期间，可归因死亡人数增加了一倍。
目的
本研究提供了1990年至2019年期间北非和中东（NAME）地区低骨矿物质密度（BMD）负担的最新估计。
方法
数据从全球疾病负担（GBD）2019研究中提取，以估计诸如死亡、伤残调整生命年（DALYs）和综合暴露值（SEV）等流行病学指标。SEV是衡量人群暴露于风险因素的指标，它考虑了风险水平下的暴露量。
结果
我们的研究结果表明，在1990 - 2019年期间，该地区低BMD导致的死亡人数和DALYs几乎增加了一倍，2019年导致20371例（95%不确定区间：14848 - 24374）死亡和805959例（630238 - 959581）DALYs。然而，年龄标准化后，DALYs和死亡率呈下降趋势。2019年，沙特阿拉伯的年龄标准化DALYs率最高，黎巴嫩最低，分别为每10万人434.2（329.6 - 534.3）和90.3（70.6 - 112.1）。低BMD导致的最高负担出现在90 - 94岁和95岁以上年龄组。此外，男女年龄标准化的低BMD的SEV均呈下降趋势。
结论
尽管年龄标准化负担指标呈下降趋势，但2019年该地区仍有相当数量的死亡和DALYs可归因于低BMD，尤其是在老年人群中。由于适当干预的积极效果将在长期内显现，强有力的策略和全面稳定的政策是实现预期目标的最终解决方案。
Zotero 插件