嵌合抗原受体 T 细胞疗法的多组学视角。

A multi-omics perspective of CAR T cell therapy.

机构信息

Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, Texas, USA.

Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, Texas, USA.

出版信息

Clin Transl Med. 2023 May;13(5):e1274. doi: 10.1002/ctm2.1274.

DOI:10.1002/ctm2.1274

PMID:37228183

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10212274/

Abstract

As omics technologies, including genomics, epigenomics, transcriptomics, T cell receptor-repertorie profiling, proteomics, metabolomics and microbiomics, have provided valuable insights into CAR T cell therapy, in our recent review, we discuss these multidimensional profiling technologies in CAR T cell research, and their potential to identify tumor-specific antigens and molecular characteristics associated with anti-tumour effects and toxicities.

摘要

随着组学技术（包括基因组学、表观基因组学、转录组学、T 细胞受体库分析、蛋白质组学、代谢组学和微生物组学）为 CAR T 细胞治疗提供了有价值的见解，在我们最近的综述中，我们讨论了这些多维分析技术在 CAR T 细胞研究中的应用，以及它们识别肿瘤特异性抗原和与抗肿瘤效果及毒性相关的分子特征的潜力。