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鼻中隔成形术后的疼痛管理:系统评价的证据。

Pain management following septorhinoplasty surgery: evidence from a systematic review.

机构信息

Department of Psychiatry and Mental Health, Alborz University of Medical Sciences, Karaj, Iran.

Student Research Committee, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.

出版信息

Eur Arch Otorhinolaryngol. 2023 Sep;280(9):3931-3952. doi: 10.1007/s00405-023-08044-3. Epub 2023 Jun 5.

Abstract

PURPOSE

We investigated recent evidence on the analgesics available for postoperative pain management among patients undergoing septoplasty or rhinoplasty surgery.

METHODS

Studies were retrieved from MEDLINE (through PubMed), Web of Science, and Embase up to 3 August 2022.

RESULTS

Forty-seven studies including 3717 patients were included. There were 45 randomized clinical trials and 2 observational cohort studies. Most of the studies were recently published and conducted in Turkey (n = 27). The majority of the studies performed the intervention preoperatively (n = 26), 11 studies postoperatively, 6 studies intraoperative, 2 studies preoperative plus intraoperative, and 2 studies performed the intervention with preoperative plus postoperative timing. The most evaluated medication was lidocaine (n = 10), followed by levobupivacaine (n = 4), and gabapentin (n = 4). Regarding post-operative pain assessment, the most used scale was the visual analog scale (VAS) (n = 36). Compared to controls, almost all interventions showed a significant benefit in managing post-operative pain. Although it should be mentioned regarding the comparison between opioids and NSAIDs consumption after surgery for pain management, most studies did not show a significant difference between the groups. No major side effects except nausea and vomiting were observed among the reviewed studies.

CONCLUSION

This study summarized the most recent options that are available to manage pain following septorhinoplasty surgery. Recent investigations showed local interventions vs pre/post-operative analgesic medications are highly suggested to be replaced with opioids and NSAIDs as they have shown prominent efficacy with no significant adverse events. Future research is advised to determine the best dosage and administration techniques.

摘要

目的

我们调查了用于鼻中隔成形术或鼻整形术患者术后疼痛管理的现有镇痛药的最新证据。

方法

检索了 MEDLINE(通过 PubMed)、Web of Science 和 Embase 截至 2022 年 8 月 3 日的研究。

结果

纳入了 47 项研究,共 3717 例患者。其中包括 45 项随机临床试验和 2 项观察性队列研究。大多数研究是最近发表的,并且在土耳其进行(n=27)。大多数研究在术前进行干预(n=26),11 项研究在术后进行,6 项研究在术中进行,2 项研究在术前加术中进行,2 项研究在术前加术后进行。评估最多的药物是利多卡因(n=10),其次是左布比卡因(n=4)和加巴喷丁(n=4)。关于术后疼痛评估,最常用的量表是视觉模拟量表(VAS)(n=36)。与对照组相比,几乎所有干预措施在管理术后疼痛方面都显示出显著的益处。尽管应该提到在术后疼痛管理中比较阿片类药物和 NSAIDs 的消耗,但大多数研究并没有显示出组间的显著差异。除了恶心和呕吐外,在综述研究中没有观察到其他主要副作用。

结论

本研究总结了目前用于鼻中隔成形术或鼻整形术后疼痛管理的最新选择。最近的研究表明,局部干预与术前/术后镇痛药物相比,建议用阿片类药物和 NSAIDs 替代,因为它们具有显著的疗效,且没有显著的不良反应。建议进行未来的研究以确定最佳剂量和给药技术。

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