金属蛋白酶介导的微生物中氧化还原信号转导。
Metalloprotein enabled redox signal transduction in microbes.
机构信息
Department of Chemistry, University of Minnesota Twin Cities, 207 Pleasant St. SE, Minneapolis MN 55414, USA.
Department of Chemistry, University of Minnesota Twin Cities, 207 Pleasant St. SE, Minneapolis MN 55414, USA.
出版信息
Curr Opin Chem Biol. 2023 Oct;76:102331. doi: 10.1016/j.cbpa.2023.102331. Epub 2023 Jun 11.
Microbes utilize numerous metal cofactor-containing proteins to recognize and respond to constantly fluctuating redox stresses in their environment. Gaining an understanding of how these metalloproteins sense redox events, and how they communicate such information downstream to DNA to modulate microbial metabolism, is a topic of great interest to both chemists and biologists. In this article, we review recently characterized examples of metalloprotein sensors, focusing on the coordination and oxidation state of the metals involved, how these metals are able to recognize redox stimuli, and how the signal is transmitted beyond the metal center. We discuss specific examples of iron, nickel, and manganese-based microbial sensors, and identify gaps in knowledge in the field of metalloprotein-based signal transduction pathways.
微生物利用许多含有金属辅因子的蛋白质来识别和响应其环境中不断变化的氧化还原应激。了解这些金属蛋白如何感知氧化还原事件，以及它们如何将这些信息向下游传递到 DNA 以调节微生物代谢，这是化学家和生物学家都非常感兴趣的话题。在本文中，我们综述了最近表征的金属蛋白传感器的例子，重点讨论了所涉及金属的配位和氧化态、这些金属如何能够识别氧化还原刺激，以及信号如何超越金属中心传递。我们讨论了基于铁、镍和锰的微生物传感器的具体例子，并确定了基于金属蛋白信号转导途径领域的知识空白。
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