生活方式相关风险因素及其与成年后海马体和全脑灰质体积的累积关联：欧洲 Lifebrain 联盟的 pooled 分析。

Lifestyle-related risk factors and their cumulative associations with hippocampal and total grey matter volume across the adult lifespan: A pooled analysis in the European Lifebrain consortium.

机构信息

Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress program, Amsterdam, the Netherlands.

出版信息

Brain Res Bull. 2023 Aug;200:110692. doi: 10.1016/j.brainresbull.2023.110692. Epub 2023 Jun 17.

DOI:10.1016/j.brainresbull.2023.110692

PMID:37336327

Abstract

BACKGROUND

Lifestyle-related risk factors, such as obesity, physical inactivity, short sleep, smoking and alcohol use, have been associated with low hippocampal and total grey matter volumes (GMV). However, these risk factors have mostly been assessed as separate factors, leaving it unknown if variance explained by these factors is overlapping or additive. We investigated associations of five lifestyle-related factors separately and cumulatively with hippocampal and total GMV, pooled across eight European cohorts.

METHODS

We included 3838 participants aged 18-90 years from eight cohorts of the European Lifebrain consortium. Using individual person data, we performed cross-sectional meta-analyses on associations of presence of lifestyle-related risk factors separately (overweight/obesity, physical inactivity, short sleep, smoking, high alcohol use) as well as a cumulative unhealthy lifestyle score (counting the number of present lifestyle-related risk factors) with FreeSurfer-derived hippocampal volume and total GMV. Lifestyle-related risk factors were defined according to public health guidelines.

RESULTS

High alcohol use was associated with lower hippocampal volume (r = -0.10, p = 0.021), and overweight/obesity with lower total GMV (r = -0.09, p = 0.001). Other lifestyle-related risk factors were not significantly associated with hippocampal volume or GMV. The cumulative unhealthy lifestyle score was negatively associated with total GMV (r = -0.08, p = 0.001), but not hippocampal volume (r = -0.01, p = 0.625).

CONCLUSIONS

This large pooled study confirmed the negative association of some lifestyle-related risk factors with hippocampal volume and GMV, although with small effect sizes. Lifestyle factors should not be seen in isolation as there is evidence that having multiple unhealthy lifestyle factors is associated with a linear reduction in overall brain volume.

摘要

背景

与生活方式相关的风险因素，如肥胖、身体活动不足、睡眠不足、吸烟和饮酒，与海马体和全脑灰质体积（GMV）减少有关。然而，这些风险因素大多被评估为单独的因素，尚不清楚这些因素所解释的方差是否存在重叠或累加。我们在八个欧洲队列中调查了五种生活方式相关因素单独和累积与海马体和总 GMV 的关系。

方法

我们纳入了来自欧洲 Lifebrain 联盟的八个队列的 3838 名年龄在 18-90 岁的参与者。使用个体数据，我们对五种生活方式相关因素（超重/肥胖、身体活动不足、睡眠不足、吸烟、饮酒过量）的存在情况进行了横断面荟萃分析，以及累积的不健康生活方式评分（计数存在的生活方式相关风险因素的数量）与 FreeSurfer 衍生的海马体体积和总 GMV 的关系。生活方式相关风险因素根据公共卫生指南定义。

结果

饮酒过量与海马体体积较小有关（r=-0.10，p=0.021），超重/肥胖与总 GMV 较小有关（r=-0.09，p=0.001）。其他生活方式相关风险因素与海马体体积或 GMV 无显著相关性。累积的不健康生活方式评分与总 GMV 呈负相关（r=-0.08，p=0.001），但与海马体体积无显著相关性（r=-0.01，p=0.625）。