免疫疗法：一种控制脑转移的新兴手段。
Immunotherapy: an emerging modality to checkmate brain metastasis.
机构信息
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE-68198, USA.
Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
出版信息
Mol Cancer. 2023 Jul 15;22(1):111. doi: 10.1186/s12943-023-01818-7.
The diagnosis of brain metastasis (BrM) has historically been a dooming diagnosis that is nothing less than a death sentence, with few treatment options for palliation or prolonging life. Among the few treatment options available, brain radiotherapy (RT) and surgical resection have been the backbone of therapy. Within the past couple of years, immunotherapy (IT), alone and in combination with traditional treatments, has emerged as a reckoning force to combat the spread of BrM and shrink tumor burden. This review compiles recent reports describing the potential role of IT in the treatment of BrM in various cancers. It also examines the impact of the tumor microenvironment of BrM on regulating the spread of cancer and the role IT can play in mitigating that spread. Lastly, this review also focuses on the future of IT and new clinical trials pushing the boundaries of IT in BrM.
脑转移（BrM）的诊断在历史上一直是一个致命的诊断，几乎等于死刑，缓解或延长生命的治疗选择很少。在为数不多的治疗选择中，脑放疗（RT）和手术切除一直是治疗的核心。在过去几年中，免疫疗法（IT）单独或与传统治疗联合应用，已成为对抗 BrM 扩散和缩小肿瘤负担的有力手段。本综述汇集了最近的报告，描述了 IT 在各种癌症中治疗 BrM 的潜力。它还研究了 BrM 的肿瘤微环境对调节癌症扩散的影响，以及 IT 在减轻这种扩散方面可以发挥的作用。最后，本综述还重点介绍了 IT 的未来和推动 BrM 中 IT 边界的新临床试验。
Zotero 插件