鞘脂代谢与癌症进展中的补体信号通路
Sphingolipid metabolism and complement signaling in cancer progression.
机构信息
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA.
Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, FL 32610, USA.
出版信息
Trends Cancer. 2023 Oct;9(10):782-787. doi: 10.1016/j.trecan.2023.07.001. Epub 2023 Jul 26.
Abstract
Cancer treatment options are limited due to therapeutic resistance; thus, understanding the tumor microenvironment (TME) is crucial. Sphingolipid metabolism and complement activation products have essential roles in promoting tumor survival. Emerging evidence shows that sphingolipid signaling can regulate intracellular complement activation to induce inflammasome-mediated metastasis, offering a promising strategy for cancer therapy.
摘要
由于治疗耐药性，癌症治疗选择有限；因此，了解肿瘤微环境（TME）至关重要。鞘脂代谢和补体激活产物在促进肿瘤存活方面发挥着重要作用。新出现的证据表明，鞘脂信号可以调节细胞内补体激活，诱导炎症小体介导的转移，为癌症治疗提供了有前途的策略。
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