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神经和精神疾病中的表观遗传学:当前认识与未来展望的全面综述

Epigenetics in Neurological and Psychiatric Disorders: A Comprehensive Review of Current Understanding and Future Perspectives.

作者信息

Grezenko Han, Ekhator Chukwuyem, Nwabugwu Nkechi U, Ganga Harshita, Affaf Maryam, Abdelaziz Ali M, Rehman Abdur, Shehryar Abdullah, Abbasi Fatima A, Bellegarde Sophia B, Khaliq Abdul Saboor

机构信息

Translational Neuroscience, Barrow Neurological Institute, Phoenix, USA.

Neuro-Oncology, New York Institute of Technology, College of Osteopathic Medicine, Old Westbury, USA.

出版信息

Cureus. 2023 Aug 23;15(8):e43960. doi: 10.7759/cureus.43960. eCollection 2023 Aug.

Abstract

The burgeoning field of epigenetics offers transformative insights into the complex landscape of neurological and psychiatric disorders. By unraveling the intricate interplay between genetic, epigenetic, environmental, and lifestyle factors, this comprehensive review highlights the multifaceted nature of mental health. The exploration reveals the potential of epigenetic modifications to revolutionize our understanding, diagnosis, treatment, and prevention of these disorders. Emphasizing the importance of multidisciplinary collaborations, large-scale studies, technological advancements, and ethical considerations, the review asserts the promise of epigenetics as a vital tool for personalized medicine, early intervention, and public health strategies. While acknowledging the challenges in a still-emerging field, the review paints an optimistic picture of epigenetics as a groundbreaking approach that can reshape mental healthcare, offering hope for those affected by neurological and psychiatric conditions. The future trajectory of the field relies on interdisciplinary efforts, ethical diligence, innovative technologies, and translating scientific insights into real-world applications, thereby unlocking the vast potential of epigenetics in mental health.

摘要

新兴的表观遗传学领域为神经和精神疾病的复杂图景提供了变革性的见解。通过揭示遗传、表观遗传、环境和生活方式因素之间错综复杂的相互作用,这篇全面综述突出了心理健康的多面性。探索揭示了表观遗传修饰在彻底改变我们对这些疾病的理解、诊断、治疗和预防方面的潜力。该综述强调了多学科合作、大规模研究、技术进步和伦理考量的重要性,断言表观遗传学有望成为个性化医疗、早期干预和公共卫生策略的重要工具。在承认这个仍在兴起的领域存在挑战的同时,该综述描绘了一幅乐观的表观遗传学图景,将其视为一种开创性的方法,能够重塑精神卫生保健,为那些受神经和精神疾病影响的人带来希望。该领域的未来轨迹依赖于跨学科努力、道德严谨、创新技术以及将科学见解转化为实际应用,从而释放表观遗传学在心理健康方面的巨大潜力。

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