靶向 EZH2 通过 Notch1 通路调节神经胶质瘤干细胞的生物学特性。
Targeting EZH2 regulates the biological characteristics of glioma stem cells via the Notch1 pathway.
机构信息
Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
Department of Neurosurgery, Suzhou Ninth People's Hospital, Suzhou, 215000, China.
出版信息
Exp Brain Res. 2023 Oct;241(10):2409-2418. doi: 10.1007/s00221-023-06693-8. Epub 2023 Aug 29.
Glioma is the most common malignant brain tumor, and its behavior is closely related to the presence of glioma stem cells (GSCs). We found that the enhancer of zeste homolog 2 (EZH2) is highly expressed in glioma and that its expression is correlated with the prognosis of glioblastoma multiforme (GBM) in two databases: The Cancer Genome Atlas and the Chinese Glioma Genome Atlas. Additionally, EZH2 is known to regulate the stemness-associated gene expression, proliferation, and invasion ability of GSCs, which may be achieved through the activation of the STAT3 and Notch1 pathways. Furthermore, we demonstrated the effect of the EZH2-specific inhibitor GSK126 on GSCs; these results not only corroborate our hypothesis, but also provide a potential novel treatment approach for glioma.
神经胶质瘤是最常见的恶性脑肿瘤，其行为与神经胶质瘤干细胞（GSCs）的存在密切相关。我们发现，在两个数据库：癌症基因组图谱和中国脑胶质瘤基因组图谱中，EZH2 高度表达于神经胶质瘤中，其表达与多形性胶质母细胞瘤（GBM）的预后相关。此外，EZH2 已知调节 GSCs 的干性相关基因表达、增殖和侵袭能力，这可能通过激活 STAT3 和 Notch1 途径来实现。此外，我们还证实了 EZH2 特异性抑制剂 GSK126 对 GSCs 的作用；这些结果不仅证实了我们的假设，而且为神经胶质瘤提供了一种潜在的新的治疗方法。
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