抗焦虑药可引起胰腺癌焦虑。
Anxiolytics cause anxiety in pancreatic cancer.
机构信息
Department of Translational Molecular Pathology, Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Trends Cancer. 2023 Nov;9(11):874-875. doi: 10.1016/j.trecan.2023.09.005. Epub 2023 Sep 29.
PMID:37778962
Abstract
Benzodiazepines (BZDs) are commonly prescribed for pancreatic cancer patients. To investigate the correlation between BZDs and survival outcomes a recent study by Cornwell et al. found that lorazepam (LOR) correlates with poor survival. The mechanistic study shows that LOR increases interleukin 6 (IL6) expression in cancer-associated fibroblasts via GPR68.
摘要
苯二氮䓬类药物（BZDs）常用于胰腺癌患者。为了研究 BZDs 与生存结果的相关性，Cornwell 等人最近的一项研究发现，劳拉西泮（LOR）与生存不良相关。机制研究表明，LOR 通过 GPR68 增加癌症相关成纤维细胞中白细胞介素 6（IL6）的表达。
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