上皮膜蛋白 3 和几丁质酶 3 样蛋白 1 作为胶质瘤的新预后预测因子：一项两基因研究。

Epithelial Membrane Protein-3 and Chitinase-3-like Protein-1 as New Prognostic Predictors of Glioma, a Two-Gene Study.

机构信息

Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China.

出版信息

Curr Oncol. 2023 Sep 23;30(10):8686-8702. doi: 10.3390/curroncol30100629.

DOI:10.3390/curroncol30100629

PMID:37887529

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10605675/

Abstract

BACKGROUND

Glioblastoma multiforme is the most common primary intracranial tumor, with a high degree of malignancy, poor therapeutic effect, and poor prognosis. According to previous studies, CHI3L1 and EMP3 are two independent tumor predictors that are of great significance for the prognostic prediction of other tumors, and their expression levels may be related to the prognosis of glioma patients.

METHODS

using Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), the Chinese Glioma Genome Atlas (CGGA), cBioPortal, LinkedOmics, and other databases, 693 glioma patients were screened to analyze the relationship between EMP3 and CHI3L1 expression and prognosis in glioma patients.

RESULTS

low-grade glioma patients with a low expression of EMP3/CHI3L1 had a better prognosis, and the combination of EMP3/CHI3L1 is a new predictor for glioma patients.

CONCLUSION

We used the TCGA and CGGA databases to analyze the effect of EMP3 and CHI3L1 expression on the prognosis of glioma patients and their correlation with gene expression using bioinformation analysis. The results showed that low-grade glioma patients with a low expression of EMP3 and CHI3L1 had a better prognosis, and EMP3 and CHI3L1 co-expression genes were correlated. The combination of these two factors could be a new prognostic index for glioma patients.

摘要

背景

多形性胶质母细胞瘤是最常见的原发性颅内肿瘤，具有高度恶性、治疗效果差、预后差的特点。根据以往的研究，CHI3L1 和 EMP3 是两个独立的肿瘤预测因子，对其他肿瘤的预后预测具有重要意义，其表达水平可能与胶质瘤患者的预后有关。

方法

利用 Oncomine、基因表达谱交互分析（GEPIA）、中国脑胶质瘤基因组图谱（CGGA）、cBioPortal、LinkedOmics 等数据库，筛选 693 例胶质瘤患者，分析 EMP3 和 CHI3L1 在胶质瘤患者中的表达与预后的关系。

结果

低级别胶质瘤患者中 EMP3/CHI3L1 低表达的患者预后较好，EMP3/CHI3L1 的联合是胶质瘤患者的新预测因子。

结论

我们使用 TCGA 和 CGGA 数据库，通过生物信息学分析，分析 EMP3 和 CHI3L1 表达对胶质瘤患者预后的影响及其与基因表达的相关性。结果表明，低级别胶质瘤患者中 EMP3 和 CHI3L1 低表达的患者预后较好，且 EMP3 和 CHI3L1 共表达基因存在相关性。这两个因素的联合可能是胶质瘤患者的一个新的预后指标。