解析免疫动态：妊娠中的 HPV 感染——来自女性视角的洞察。

Unraveling Immunological Dynamics: HPV Infection in Women-Insights from Pregnancy.

机构信息

Department of Obstetrics and Gynecology, Polizu Clinical Hospital, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania.

Department of Genetics, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania.

出版信息

Viruses. 2023 Sep 27;15(10):2011. doi: 10.3390/v15102011.

DOI:10.3390/v15102011

PMID:37896788

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10611104/

Abstract

During pregnancy, hormonal and immune adaptations are vital for supporting the genetically distinct fetus during elevated infection risks. The global prevalence of HPV necessitates its consideration during pregnancy. Despite a seemingly mild immune response, historical gestational viral infections underscore its significance. Acknowledging the established HPV infection risks during pregnancy, our review explores the unfolding immunological changes in pregnant women with HPV. Our analysis aims to uncover strategies for safely modulating the immune system, mitigating adverse pregnancy consequences, and enhancing maternal and child health. This comprehensive narrative review delves into the existing knowledge and studies on this topic.

摘要

在怀孕期间，激素和免疫适应对于在感染风险增加的情况下支持基因上不同的胎儿至关重要。HPV 的全球流行率需要在怀孕期间考虑到它。尽管免疫反应看似轻微，但历史上妊娠病毒感染强调了其重要性。鉴于怀孕期间 HPV 感染的既定风险，我们的综述探讨了 HPV 感染孕妇中免疫的变化。我们的分析旨在揭示安全调节免疫系统、减轻不良妊娠后果以及改善母婴健康的策略。本全面的叙述性综述深入探讨了这一主题的现有知识和研究。