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支架在组织工程中的应用:当前利用与未来展望。

Applications of Scaffolds in Tissue Engineering: Current Utilization and Future Prospective.

机构信息

Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.

出版信息

Curr Gene Ther. 2024;24(2):94-109. doi: 10.2174/0115665232262167231012102837.

Abstract

Current regenerative medicine tactics focus on regenerating tissue structures pathologically modified by cell transplantation in combination with supporting scaffolds and biomolecules. Natural and synthetic polymers, bioresorbable inorganic and hybrid materials, and tissue decellularized were deemed biomaterials scaffolding because of their improved structural, mechanical, and biological abilities.Various biomaterials, existing treatment methodologies and emerging technologies in the field of Three-dimensional (3D) and hydrogel processing, and the unique fabric concerns for tissue engineering. A scaffold that acts as a transient matrix for cell proliferation and extracellular matrix deposition, with subsequent expansion, is needed to restore or regenerate the tissue. Diverse technologies are combined to produce porous tissue regenerative and tailored release of bioactive substances in applications of tissue engineering. Tissue engineering scaffolds are crucial ingredients. This paper discusses an overview of the various scaffold kinds and their material features and applications. Tabulation of the manufacturing technologies for fabric engineering and equipment, encompassing the latest fundamental and standard procedures.

摘要

目前的再生医学策略侧重于通过细胞移植与支持性支架和生物分子结合,来再生组织结构。天然和合成聚合物、生物可吸收无机和混合材料以及组织去细胞化被认为是生物材料支架,因为它们具有改善的结构、机械和生物学性能。各种生物材料、现有的治疗方法和新兴技术在三维(3D)和水凝胶处理领域,以及组织工程的独特织物问题。需要一个支架作为细胞增殖和细胞外基质沉积的临时基质,随后进行扩展,以恢复或再生组织。多种技术结合在一起,用于组织工程中的多孔组织再生和生物活性物质的定制释放。组织工程支架是关键成分。本文讨论了各种支架类型及其材料特性和应用的概述。编制了织物工程制造技术和设备的表格,包括最新的基本和标准程序。

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