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用于再生医学的干细胞移植的进展与挑战。

Advancements and challenges in stem cell transplantation for regenerative medicine.

作者信息

Wei Lingxi, Yan Wenqi, Shah Wahid, Zhang Zhengwei, Wang Minghe, Liu Biao, Xue Zhentong, Cao Yixin, Hou Xinyu, Zhang Kai, Yan Beibei, Wang Xiaogang

机构信息

Shanxi Medical University, Tai Yuan, Shanxi, 030607, China.

Shandong University, Ji Nan, Shandong, 250000, China.

出版信息

Heliyon. 2024 Aug 10;10(16):e35836. doi: 10.1016/j.heliyon.2024.e35836. eCollection 2024 Aug 30.

Abstract

Stem cell transplantation has emerged as a promising avenue in regenerative medicine, potentially facilitating tissue repair in degenerative diseases and injuries. This review comprehensively examines recent developments and challenges in stem cell transplantation. It explores the identification and isolation of various stem cell types, including embryonic, induced pluripotent, and adult stem cells derived from multiple sources. Additionally, the review highlights the tissue-specific applications of these stem cells, focusing on bone and cartilage regeneration, treatment of neurological disorders, and management of hematological conditions. Future advancements and effective resolution of current challenges will be crucial in fully realizing the potential of stem cell transplantation in regenerative medicine. With responsible and ethical practices, the field can potentially transform disease and injury treatment, ultimately improving the quality of life for countless individuals.

摘要

干细胞移植已成为再生医学中一条充满前景的途径,有可能促进退行性疾病和损伤的组织修复。本综述全面审视了干细胞移植的最新进展和挑战。它探讨了各种干细胞类型的识别与分离,包括胚胎干细胞、诱导多能干细胞以及源自多种来源的成体干细胞。此外,该综述着重介绍了这些干细胞在组织特异性方面的应用,重点关注骨与软骨再生、神经系统疾病的治疗以及血液疾病的管理。未来的进展以及当前挑战的有效解决对于充分实现干细胞移植在再生医学中的潜力至关重要。通过负责任且符合伦理的实践,该领域有可能改变疾病和损伤的治疗方式,最终改善无数人的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7939/11379611/44f1fab074d8/ga1.jpg

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