E2A-PBX1 融合在 B 细胞急性淋巴细胞白血病中的研究进展。
The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia.
机构信息
Department of Paediatrics (Children Haematological Oncology), Birth Defects and Childhood Haematological Oncology Laboratory, Sichuan Clinical Research Centre for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan, China.
Department of Paediatrics, Southwest Medical University, Luzhou, Sichuan, China.
出版信息
Ann Hematol. 2024 Sep;103(9):3385-3398. doi: 10.1007/s00277-023-05595-7. Epub 2023 Dec 27.
The E2A-PBX1 gene fusion is a common translocation in B-cell acute lymphoblastic leukaemia. Patients harbouring the E2A-PBX1 fusion gene typically exhibit an intermediate prognosis. Furthermore, minimal residual disease has unsatisfactory prognostic value in E2A-PBX1 B-cell acute lymphoblastic leukaemia. However, the mechanism of E2A-PBX1 in the occurrence and progression of B-cell acute lymphoblastic leukaemia is not well understood. Here, we mainly review the roles of E2A and PBX1 in the differentiation and development of B lymphocytes, the mechanism of E2A-PBX1 gene fusion in B-cell acute lymphoblastic leukaemia, and the potential therapeutic approaches.
E2A-PBX1 基因融合是 B 细胞急性淋巴细胞白血病的常见易位。携带 E2A-PBX1 融合基因的患者通常表现出中等预后。此外，微小残留病在 E2A-PBX1 B 细胞急性淋巴细胞白血病中的预后价值并不理想。然而，E2A-PBX1 在 B 细胞急性淋巴细胞白血病发生和进展中的机制尚不清楚。在这里，我们主要综述 E2A 和 PBX1 在 B 淋巴细胞分化和发育中的作用、E2A-PBX1 基因融合在 B 细胞急性淋巴细胞白血病中的作用机制以及潜在的治疗方法。
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