基于营养的指标在预测乳腺癌患者生存率中的作用：一项系统评价和荟萃分析。
The role of nutrition-based index in predicting survival of breast cancer patients: A systematic review and meta-analysis.
作者信息
Prasetiyo Patricia Diana, Baskoro Bernard Agung, Hariyanto Timotius Ivan
机构信息
Department of Pathology, Faculty of Medicine, Pelita Harapan University, Tangerang, Banten, 15811, Indonesia.
Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Pelita Harapan University, Karawaci, Tangerang, 15811, Indonesia.
出版信息
Heliyon. 2023 Dec 11;10(1):e23541. doi: 10.1016/j.heliyon.2023.e23541. eCollection 2024 Jan 15.
BACKGROUND
Prognostic nutritional index (PNI) and Controlling Nutritional Status (CONUT) are two model that incorporates the role of inflammation and nutrition factors to predict the progression of tumor. The primary objective of this investigation is to examine the ability of PNI and CONUT score for predicting the survival in breast cancer patients.
METHODS
A comprehensive search was conducted on the Cochrane Library, Scopus, Europe PMC, and Medline databases up until August 14th, 2023, utilizing a combination of relevant keywords. This review incorporates literature that examines the relationship between PNI, CONUT, and survival in breast cancer. We employed random-effect models to analyze the hazard ratio (HR) and present the outcomes together with their corresponding 95 % confidence intervals (CI).
RESULTS
A total of sixteen studies were incorporated. The results of our meta-analysis indicated that high PNI was associated with better overall survival (OS) (HR 0.38; 95%CI: 0.28-0.51, < 0.00001, = 32 %), but not disease-free survival (DFS) (HR 0.60; 95%CI: 0.33-1.10, = 0.10, = 78 %) than low PNI in breast cancer patients. Meta-analysis also indicated that high CONUT was associated with worse OS (HR 1.66; 95%CI: 1.21-2.28, = 0.002, = 78 %) and worse DFS (HR 2.09; 95%CI: 1.60-2.73, < 0.00001, = 41 %) in breast cancer patients.
CONCLUSIONS
This study suggests the prognostic role of both PNI and CONUT score for predicting survival in breast cancer patients.
背景
预后营养指数（PNI）和控制营养状况（CONUT）是两种纳入炎症和营养因素作用以预测肿瘤进展的模型。本研究的主要目的是检验PNI和CONUT评分预测乳腺癌患者生存的能力。
方法
截至2023年8月14日，在Cochrane图书馆、Scopus、欧洲生物医学中心（Europe PMC）和Medline数据库上进行了全面检索，使用了相关关键词的组合。本综述纳入了研究PNI、CONUT与乳腺癌生存之间关系的文献。我们采用随机效应模型分析风险比（HR），并呈现结果及其相应的95%置信区间（CI）。
结果
共纳入16项研究。我们的荟萃分析结果表明，在乳腺癌患者中，高PNI与更好的总生存期（OS）相关（HR 0.38；95%CI：0.28 - 0.51，P < 0.00001，I² = 32%），但与无病生存期（DFS）无关（HR 0.60；95%CI：0.33 - 1.10，P = 0.10，I² = 78%）。荟萃分析还表明，高CONUT与乳腺癌患者更差的OS（HR 1.66；95%CI：1.21 - 2.28，P = 0.002，I² = 78%）和更差的DFS（HR 2.09；95%CI：1.60 - 2.73，P < 0.00001，I² = 41%）相关。
结论
本研究表明PNI和CONUT评分在预测乳腺癌患者生存方面具有预后作用。
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