2-吡啶酮配体促进的钯催化叔醛的-C(sp)-H键芳基化反应
Palladium-Catalyzed -C(sp)-H Bond Arylation of Tertiary Aldehydes Facilitated by 2-Pyridone Ligands.
作者信息
Xu Ziting, Li Zhi, Liu Chong, Yang Ke, Ge Haibo
机构信息
Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
出版信息
Molecules. 2024 Jan 3;29(1):259. doi: 10.3390/molecules29010259.
2-Pyridone ligand-facilitated palladium-catalyzed direct C-H bond functionalization via the transient directing group strategy has become an attractive topic. Here, we report a Pd-catalyzed direct -C(sp)-H arylation reaction of tertiary aliphatic aldehydes by using an -amino acid as a transient directing group in combination with a 2-pyridone ligand.
通过瞬态导向基团策略实现的2-吡啶酮配体促进的钯催化直接C-H键官能团化已成为一个引人关注的课题。在此，我们报道了一种钯催化的叔脂肪醛的直接-C(sp)-H芳基化反应，该反应使用一种氨基酸作为瞬态导向基团，并结合一种2-吡啶酮配体。
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