伊拉克新出现的肺炎球菌血清型：改进疫苗开发的空间。
Emerging pneumococcal serotypes in Iraq: scope for improved vaccine development.
机构信息
Al Immamin al kadhimin Medical City, Baghdad, 10011, Iraq.
Merit consultant pediatrician, Baghdad, 10011, Iraq.
出版信息
F1000Res. 2023 Dec 28;12:435. doi: 10.12688/f1000research.132781.2. eCollection 2023.
Pneumococcal disease is a global public health concern as it affects the young, aged and the immunocompromised. The development of pneumococcal vaccines and their incorporation in the immunization programs has helped to reduce the global burden of disease. However, serotype replacement and the emergence of non-vaccine serotypes as well as the persistence of a few vaccine serotypes underscores the need for development of new and effective vaccines against such pneumococcal serotypes. In the Middle East, places of religious mass gatherings are a hotspot for disease transmission in addition to the global risk factors. Therefore, the periodic surveillance of pneumococcal serotypes circulating in the region to determine the effectiveness of existing prevention strategies and develop improved vaccines is warranted. Currently, there is a lack of serotype prevalence data for Iraq due to inadequate surveillance in the region. Thus, this review aims to determine the pneumococcal serotypes circulating in Iraq which may help in the development and introduction of improved pneumococcal vaccines in the country.
肺炎球菌病是一个全球性的公共卫生关注点，因为它会影响到儿童、老年人和免疫功能低下者。肺炎球菌疫苗的开发及其纳入免疫规划有助于减轻疾病的全球负担。然而，血清型替换以及非疫苗血清型的出现和少数疫苗血清型的持续存在，突显了需要针对这些肺炎球菌血清型开发新的、有效的疫苗。在中东，宗教集会场所除了存在全球风险因素外，也是疾病传播的热点。因此，有必要定期监测该地区流行的肺炎球菌血清型，以确定现有预防策略的效果，并开发改良疫苗。目前，由于该地区监测不足，伊拉克缺乏血清型流行数据。因此，本综述旨在确定在伊拉克流行的肺炎球菌血清型，这可能有助于在该国开发和引入改良的肺炎球菌疫苗。
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