体内巨噬细胞工程作为一种新型的治疗肝转移的策略。

In vivo macrophage engineering as novel therapeutic strategy against liver metastasis.

机构信息

Laboratory of Myeloid Cell Biology in Tissue Homeostasis and Regeneration, VIB Center for Inflammation Research, Technologiepark-Zwijnaarde 71, Ghent, Belgium; Department of Biomedical Molecular Biology, Faculty of Sciences, Ghent University, Ghent, Belgium.

出版信息

Trends Cancer. 2024 Mar;10(3):175-176. doi: 10.1016/j.trecan.2024.01.012. Epub 2024 Feb 13.

DOI:10.1016/j.trecan.2024.01.012

PMID:38355357

Abstract

In a recent study, Kerzel et al. report a novel therapeutic strategy to engineer tumor-associated macrophages (TAMs) in vivo by inducing the expression of IFNα in these cells. This approach enables improved antigen presentation and T cell activation, leading to controlled tumor growth in multiple murine models of liver metastasis.

摘要

在最近的一项研究中，Kerzel 等人报告了一种新的治疗策略，通过在这些细胞中诱导 IFNα 的表达来工程化肿瘤相关巨噬细胞（TAMs）。这种方法能够改善抗原呈递和 T 细胞激活，从而控制多个肝转移的小鼠模型中的肿瘤生长。