口腔鳞状细胞癌中免疫组织化学标志物的评估
Evaluation of immuno-histochemical markers in oral squamous cell carcinoma.
作者信息
Guruprasad Yadavalli, Singhal Priya, Gupta Neha, Kukreja Bhavna Jha, Gupta Bharti, Kukreja Pankaj, Makkad Ramanpal Singh, Mehta Dhaval Niranjan
机构信息
Department of Dentistry, Vijaynagar Institute of Medical Sciences, VIMS Campus, Cantonment, Ballari - 583104, India.
Senior Resident, Department of Dentistry, SMS Medical College, Jaipur, India.
出版信息
Bioinformation. 2023 Dec 31;19(13):1399-1404. doi: 10.6026/973206300191399. eCollection 2023.
Evaluation of immuno-histochemical (IHC) markers like p53, p63, PDPN, C-erb-B2, CK19, and VEGF in oral squamous cell carcinoma (OSCCs) is of interest to dentists. Sixty formalin-fixed paraffin embedded tissue blocks from the Department of Oral Pathology, New Horizon Dental College and Research, Institute, Sakri, Bilaspur, Chhattisgarh, India. The conventional IHC method was used to assess the expression of p53, p63, PDPN, C- erb-B2, CK19 and VEGF using the different antibodies. Data shows that P53, p63 had high values of labeling index (LI) of staining while PDPN, C-erb-B2 had low values of LI of staining. The values of LI of staining for CK19, and VEGF were in between the two types of IHCs. Combining the analysis of multiple IHC markers for OSCC can yield precise cancer diagnosis results.
对口腔鳞状细胞癌（OSCC）中p53、p63、PDPN、C-erb-B2、CK19和VEGF等免疫组织化学（IHC）标志物的评估受到牙医的关注。来自印度恰蒂斯加尔邦比拉斯布尔市萨克里新地平线牙科学院和研究所口腔病理科的60个福尔马林固定石蜡包埋组织块。采用传统免疫组织化学方法，使用不同抗体评估p53、p63、PDPN、C-erb-B2、CK19和VEGF的表达。数据显示，P53、p63的染色标记指数（LI）值较高，而PDPN、C-erb-B2的染色LI值较低。CK19和VEGF的染色LI值介于两种免疫组织化学类型之间。联合分析多种OSCC免疫组织化学标志物可得出精确的癌症诊断结果。
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