拉司与癌症抗争：漫长岁月

It took a long, long time: Ras and the race to cure cancer.

机构信息

Whitehead Institute for Biomedical Research, Cambridge, MA, USA; MIT Department of Biology, Cambridge, MA, USA.

出版信息

Cell. 2024 Mar 28;187(7):1574-1577. doi: 10.1016/j.cell.2024.02.042.

DOI:10.1016/j.cell.2024.02.042

Abstract

Discoveries of the roles of RAS oncogenes in cancer development four decades ago opened the door to proving that tumor development is driven by somatic mutations' altering the genomes of cancer cells. These discoveries led to illusions about the simplicity of cancer pathogenesis and how cancer could be cured.

摘要

四十年前，人们发现 RAS 癌基因在癌症发展中的作用，这为证明肿瘤的发展是由体细胞突变改变癌细胞基因组驱动的提供了证据。这些发现导致了人们对癌症发病机制的简单性以及癌症如何被治愈的幻想。