儿童和青少年良性关节过度活动综合征与头痛的相关性。
Correlation between benign joint hypermobility syndrome and headache in children and adolescents.
机构信息
Department of Pediatric Rheumatology, Imam Hossein Children's Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
BMC Musculoskelet Disord. 2024 May 2;25(1):347. doi: 10.1186/s12891-024-07473-3.
BACKGROUND
Benign Joint Hypermobility Syndrome (BJHS) is a most common hereditary connective tissue disorders in children and adolescents. This study aimed to investigate the prevalence and subtypes of headache in children with BJHS.
METHODS
This observational-analytical study was conducted in a case-control setting on school children aged 7 to 16 years in 2021-2023 in Isfahan, Iran. Students were examined for BJHS using Beighton criteria by a pediatric rheumatologist. Headache disorder was diagnosed according to the Child Headache-Attributed Restriction, Disability, and Social Handicap and Impaired Participation (HARDSHIP) questionnaires for child and adolescent and International Classification of Headache Disorders (ICHD-III).
RESULTS
A total of 4,832 student (mean age 10.3 ± 3.1 years), 798 patients with BJHS and 912 healthy children were evaluated. The probability of headache in children aged 7-11 with hypermobility was 3.7 times lower than in children aged 12-16 with hypermobility (P = 0.001). The occurrence of headache in children with BJHS was more than the control group (P = 0.001), and the probability of headache in children with BJHS was 3.7 times higher than in healthy children (P = 0.001). Migraine was the most common headache type reported of total cases. The probability of migraine in children with BJHS was 4.5 times higher than healthy children ( P = 0.001).
CONCLUSION
This study showed a significant correlation between BJHS and headache (especially migraine) in children and adolescents.
背景
良性关节活动过度综合征（BJHS）是儿童和青少年中最常见的遗传性结缔组织疾病。本研究旨在调查 BJHS 患儿头痛的患病率和亚型。
方法
本观察性分析研究于 2021 年至 2023 年在伊朗伊斯法罕的学校儿童中进行，采用病例对照设计，研究对象为 7 至 16 岁的儿童。由儿科风湿病学家使用 Beighton 标准评估学生是否患有 BJHS。根据儿童头痛归因的限制、残疾和社会障碍以及受损参与（HARDSHIP）问卷和国际头痛疾病分类（ICHD-III）诊断头痛障碍。
结果
共评估了 4832 名学生（平均年龄 10.3±3.1 岁）、798 名 BJHS 患儿和 912 名健康儿童。7-11 岁有活动过度的儿童发生头痛的概率比 12-16 岁有活动过度的儿童低 3.7 倍（P=0.001）。BJHS 患儿头痛的发生率高于对照组（P=0.001），BJHS 患儿头痛的发生率比健康儿童高 3.7 倍（P=0.001）。偏头痛是报告的所有病例中最常见的头痛类型。BJHS 患儿偏头痛的概率比健康儿童高 4.5 倍（P=0.001）。
结论
本研究表明 BJHS 与儿童和青少年头痛（尤其是偏头痛）之间存在显著相关性。
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