Suppr超能文献

脊柱转移瘤管理的新时代。

A new era in the management of spinal metastasis.

作者信息

Morimoto Tadatsugu, Toda Yu, Hakozaki Michiyuki, Paholpak Permsak, Watanabe Kazuyuki, Kato Kinshi, Tsukamoto Masatsugu, Hirata Hirohito, Kaneuchi Yoichi, Tome Yasunori, Nagamine Satomi, Nishida Kotaro, Katsuya Hiroo, Matsumoto Yoshihiro, Otani Koji, Mawatari Masaaki, Nikaido Takuya

机构信息

Department of Orthopedic Surgery, Faculty of Medicine, Saga University, Saga, Japan.

Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan.

出版信息

Front Oncol. 2024 Apr 16;14:1374915. doi: 10.3389/fonc.2024.1374915. eCollection 2024.

Abstract

Despite the recent advances in cancer treatment, the incidence of patients with spinal metastases continues to grow along with the total number of cancer patients. Spinal metastases can significantly impair activities of daily living (ADL) and quality of life (QOL), compared with other types of bone metastases, as they are characterized with severe pain and paralysis caused by skeletal-related events. Reduced ADL can also lead to treatment limitations as certain anticancer agents and radiation therapy are not compatible treatments; thus, leading to a shorter life expectancy. Consequently, maintaining ADLs in patients with spinal metastases is paramount, and spine surgeons have an integral role to play in this regard. However, neurosurgeon, orthopedic and spinal surgeons in Japan do not have a proactive treatment approach to spinal metastases, which may prevent them from providing appropriate treatment when needed (clinical inertia). To overcome such endemic inertia, it is essential for 1) spine surgeons to understand and be more actively involved with patients with musculoskeletal disorders (cancer locomo) and cancer patients; 2) the adoption of a multidisciplinary approach (coordination and meetings not only with the attending oncologist but also with spine surgeons, radiologists, rehabilitation specialists, and other professionals) to preemptive treatment such as medication, radiotherapy, and surgical treatment; and 3) the integration of the latest findings associated with minimally invasive spinal treatments that have expanded the indications for treatment of spinal metastases and improved treatment outcomes. This heralds a new era in the management of spinal metastases.

摘要

尽管癌症治疗最近取得了进展,但脊柱转移瘤患者的发病率仍随着癌症患者总数的增加而持续上升。与其他类型的骨转移相比,脊柱转移瘤可显著损害日常生活活动能力(ADL)和生活质量(QOL),因为其特征是由骨相关事件引起的严重疼痛和瘫痪。ADL的降低也可能导致治疗受限,因为某些抗癌药物和放射治疗不相容;因此,导致预期寿命缩短。因此,维持脊柱转移瘤患者的ADL至关重要,脊柱外科医生在这方面起着不可或缺的作用。然而,日本的神经外科医生、骨科和脊柱外科医生对脊柱转移瘤没有积极的治疗方法,这可能会使他们在需要时无法提供适当的治疗(临床惰性)。为了克服这种普遍存在的惰性,对于1)脊柱外科医生来说,了解并更积极地参与肌肉骨骼疾病患者(癌症运动障碍)和癌症患者的治疗;2)采用多学科方法(不仅与主治肿瘤学家协调并开会,还要与脊柱外科医生、放射科医生、康复专家和其他专业人员协调并开会)进行药物治疗、放射治疗和手术治疗等预防性治疗;3)整合与微创脊柱治疗相关的最新研究结果,这些研究结果扩大了脊柱转移瘤的治疗适应症并改善了治疗效果。这预示着脊柱转移瘤管理的新时代。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3841/11062132/dcf2ecc311c5/fonc-14-1374915-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验