Anti- activity of rose hip oil-solid lipid nanoparticles.

is a highly prevalent pathogen, reported from almost all geographical regions of the world. Current anti- drugs are not effective enough in immunocompromised patients, encephalitis, chorioretinitis, and congenital toxoplasmosis. Therefore, the prescription of these drugs has been limited. Rose hip oil (RhO) is a natural plant compound, which shows antibacterial, anticancer, and anti-inflammatory activities. In the current study, the anti- and cell toxicity effects of solid lipid nanoparticles (SLNs) loaded by RhO (RhO-SLNs) were evaluated. Emulsification sonicated-homogenization method was used to prepare SLNs. RhO-SLNs were characterized, and their anti- and cell toxicity effects were evaluated using in vitro analyses. The particle size and the zeta potential of the nanoparticles were 152.09 nm and -15.3 mV nm, respectively. The entrapment efficiency percentage was 79.1%. In the present study, the inhibitory concentration (IC) against was >1 μg/mL (-value <.0001). The cell toxicity assay showed cytotoxicity concentration (CC) >10 mg/mL (-value = .017). In addition, at least 75% of -infected Vero cells remained alive at concentrations >10 mg/mL. The concentration of 1 mg/mL showed highest anti- activity and lowest cell toxicity against the Vero cell. Our findings suggest that carrying natural plant compounds with SLNs could be considered an effective option for treatment strategies against infections.