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Structural and functional evidence that GPR30 is not a direct estrogen receptor.

作者信息

Liu Heng, Guo Shimeng, Dai Antao, Xu Peiyu, Li Xin, Huang Sijie, He Xinheng, Wu Kai, Zhang Xinyue, Yang Dehua, Xie Xin, Xu H Eric

机构信息

The State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

The State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

出版信息

Cell Res. 2024 Jul;34(7):530-533. doi: 10.1038/s41422-024-00963-y. Epub 2024 May 14.

Abstract
摘要

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本文引用的文献

1
The G protein-coupled oestrogen receptor GPER in health and disease: an update.
Nat Rev Endocrinol. 2023 Jul;19(7):407-424. doi: 10.1038/s41574-023-00822-7. Epub 2023 May 16.
2
Multiplex G Protein-Coupled Receptor Screen Reveals Reliably Acting Agonists and a Gq-Phospholipase C Coupling Mode of GPR30/GPER1.
Mol Pharmacol. 2023 Feb;103(2):48-62. doi: 10.1124/molpharm.122.000580. Epub 2022 Nov 18.
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Role of estrogen receptors in health and disease.
Front Endocrinol (Lausanne). 2022 Aug 18;13:839005. doi: 10.3389/fendo.2022.839005. eCollection 2022.
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Structures of the glucocorticoid-bound adhesion receptor GPR97-G complex.
Nature. 2021 Jan;589(7843):620-626. doi: 10.1038/s41586-020-03083-w. Epub 2021 Jan 6.
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Does GPER Really Function as a G Protein-Coupled Estrogen Receptor ?
Front Endocrinol (Lausanne). 2020 Mar 31;11:148. doi: 10.3389/fendo.2020.00148. eCollection 2020.
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Estrogen receptor signaling mechanisms.
Adv Protein Chem Struct Biol. 2019;116:135-170. doi: 10.1016/bs.apcsb.2019.01.001. Epub 2019 Feb 4.
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Structure of the human κ-opioid receptor in complex with JDTic.
Nature. 2012 Mar 21;485(7398):327-32. doi: 10.1038/nature10939.
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Involvement of estrogen receptor variant ER-alpha36, not GPR30, in nongenomic estrogen signaling.
Mol Endocrinol. 2010 Apr;24(4):709-21. doi: 10.1210/me.2009-0317. Epub 2010 Mar 2.
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G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not activated by estradiol.
Endocrinology. 2008 Oct;149(10):4846-56. doi: 10.1210/en.2008-0269. Epub 2008 Jun 19.

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