Suppr超能文献

年轻人群关节镜手术后阿片类药物的使用及处置策略:一项前瞻性观察研究

Postoperative Opioid Usage and Disposal Strategies After Arthroscopic Procedures in a Young Cohort: A Prospective Observational Study.

作者信息

Johns William L, Johnson Emma E, Brutico Joseph, Sherman Matthew B, Freedman Kevin B, Emper William, Salvo John P, Hammoud Sommer

机构信息

Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

出版信息

Orthop J Sports Med. 2024 May 15;12(5):23259671241249688. doi: 10.1177/23259671241249688. eCollection 2024 May.

Abstract

BACKGROUND

Although several studies have noted that patients are routinely overprescribed opioids, few have reported usage after arthroscopic surgery.

PURPOSE

To determine opioid consumption and allocation for unused opioids after common arthroscopic surgeries.

STUDY DESIGN

Case series; Level of evidence, 4.

METHODS

Patients between the ages of 15 and 40 years who were scheduled to undergo anterior cruciate ligament reconstruction (ACLR), labral repair of the hip or shoulder, meniscectomy, or meniscal repair were prospectively enrolled. Patients were prescribed either 5 mg hydrocodone-325 mg acetaminophen or 5 mg oxycodone-325 mg acetaminophen based on surgeon preference. Patients completed a daily opioid usage survey during the 2-week postoperative period. In addition, patients completed a survey on postoperative day 21 inquiring about continued opioid use and medication disposal, if applicable. Opioid medication consumption was converted to morphine milligram equivalents (MMEs).

RESULTS

Of the 200 patients who were enrolled in the study, 176 patients had sufficient follow-up after undergoing 85 (48%) ACLR, 26 (14.8%) hip labral repair, 34 (19.3%) shoulder labral repair, 18 (10.2%) meniscectomy, and 13 (7.4%) meniscal repair procedures. Mean age was 26.1 years (SD, 7.38); surgeons prescribed a mean of 26.6 pills whereas patients reported consuming a mean of 15.5 pills. The mean MME consumption in the 14 days after each procedure was calculated: ACLR (95.7; 44% of prescription), hip labral repair (84.8; 37%), shoulder labral repair (57.2; 35%), meniscectomy (18.4; 27%), and meniscal repair (32.1; 42%). This corresponded to approximately 39% of the total opioid prescription being utilized across all procedures. Mean MME consumption was greatest on postoperative day 1 in hip, shoulder, and meniscal procedures and on postoperative day 2 in ACLR. Only 7.04% of patients reported continued opioid use in the third postoperative week. Patients had a mean of 11 unused pills or 77.7 MMEs remaining. Of the patients with remaining medication, 24.7% intended to keep their medication for future use.

CONCLUSION

The results of our study indicate that patients who undergo the aforementioned arthroscopic procedures consume <75 MMEs in the 2-week postoperative period, translating into a mean of 10 to 15 pills consumed. Approximately 60% of total opioids prescribed went unused, and one-fourth of patients intended to keep their remaining medication for future usage. We have provided general prescribing guidelines and recommend that surgeons carefully consider customizing their opioid prescriptions on the basis of procedure site to balance optimal postoperative analgesia with avoidance of dissemination of excess opioids.

摘要

背景

尽管多项研究指出患者经常被过度开具阿片类药物,但很少有研究报告关节镜手术后的使用情况。

目的

确定常见关节镜手术后阿片类药物的消耗量以及未使用阿片类药物的去向。

研究设计

病例系列;证据等级,4级。

方法

前瞻性纳入年龄在15至40岁之间、计划接受前交叉韧带重建(ACLR)、髋部或肩部盂唇修复、半月板切除术或半月板修复的患者。根据外科医生的偏好,为患者开具5毫克氢可酮-325毫克对乙酰氨基酚或5毫克羟考酮-325毫克对乙酰氨基酚。患者在术后2周内完成每日阿片类药物使用情况调查。此外,患者在术后第21天完成一项调查,询问是否继续使用阿片类药物以及药物处置情况(如适用)。阿片类药物消耗量转换为吗啡毫克当量(MME)。

结果

在纳入研究的200例患者中,176例患者在接受85例(48%)ACLR、26例(14.8%)髋部盂唇修复、34例(19.3%)肩部盂唇修复、18例(10.2%)半月板切除术和13例(7.4%)半月板修复手术后有足够的随访数据。平均年龄为26.1岁(标准差,7.38);外科医生平均开具26.6片药,而患者报告平均服用15.5片。计算了每种手术后14天内的平均MME消耗量:ACLR(95.7;占处方的44%)、髋部盂唇修复(84.8;占37%)、肩部盂唇修复(�7.2;占35%)、半月板切除术(18.4;占27%)和半月板修复(32.1;占42%)。这相当于所有手术中约39%的阿片类药物处方被使用。在髋部、肩部和半月板手术中,术后第1天的平均MME消耗量最大,在ACLR中术后第2天最大。只有7.04%的患者报告在术后第三周继续使用阿片类药物。患者平均剩余11片未使用的药或77.7 MME。在有剩余药物的患者中,24.7%打算保留药物以备将来使用。

结论

我们的研究结果表明,接受上述关节镜手术的患者在术后2周内消耗的MME<75,平均服用10至15片药。约60%的阿片类药物处方未被使用,四分之一的患者打算保留剩余药物以备将来使用。我们提供了一般的处方指南,并建议外科医生根据手术部位仔细考虑定制阿片类药物处方,以在避免过量阿片类药物传播的同时平衡最佳术后镇痛效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d2c/11097716/ba549e73cc65/10.1177_23259671241249688-fig1.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验