老年人营养不良与抑郁风险关联的系统评价和荟萃分析
Systematic Review and Meta-analysis of the Association Between Malnutrition and Risk of Depression in the Elderly.
作者信息
Hu Weiwei, Mao Huiping, Guan Shasha, Jin Jia, Xu Dan
机构信息
Department of General Surgery, Taizhou First People's Hospital, Zhejiang, China.
Department of Nursing, Taizhou First People's Hospital, Zhejiang, China.
出版信息
Alpha Psychiatry. 2024 Mar 1;25(2):183-189. doi: 10.5152/alphapsychiatry.2024.231336. eCollection 2024 Mar.
OBJECTIVE
To explore the association between malnutrition and risk of depression in the elderly.
METHODS
Relevant studies were searched in PubMed, Web of Science, the Cochrane Library, Scopus, and Embase from the establishment of the database to August 17, 2023. Two researchers independently screened the literature, extracted data, and evaluated the risk of bias in the included studies. Stata16.0 software was used for meta-analysis.
RESULTS
A total of 8 observational studies were identified with 11 112 participants, of which 2771 elderly patients had depression. The meta-pooled results showed a significant correlation between nutritional status and depression risk (odds ratio (OR) = 2.03, 95% CI = (1.47, 2.81), < 0.001). Subgroup analysis found that the malnutrition scores of different study types and the diagnostic methods of depression and malnutrition were correlated with the risk of depression.
CONCLUSION
Malnutrition was associated with depression risk in the elderly. Further large-scale multicenter studies should be conducted to test and verify the results.
目的
探讨老年人营养不良与抑郁症风险之间的关联。
方法
在PubMed、科学网、考克兰图书馆、Scopus和Embase数据库中检索从建库至2023年8月17日的相关研究。两名研究人员独立筛选文献、提取数据并评估纳入研究的偏倚风险。使用Stata16.0软件进行荟萃分析。
结果
共纳入8项观察性研究，涉及11112名参与者，其中2771名老年患者患有抑郁症。荟萃合并结果显示营养状况与抑郁症风险之间存在显著相关性（优势比（OR）=2.03，95%置信区间（CI）=(1.47, 2.81)，<0.001）。亚组分析发现，不同研究类型的营养不良评分以及抑郁症和营养不良的诊断方法与抑郁症风险相关。
结论
营养不良与老年人的抑郁症风险相关。应开展进一步的大规模多中心研究以检验和验证该结果。
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